Investigation of Water-Soluble X-ray Luminescence Nanoparticles for Biomedical Applications
EMSL Project ID
30431
Abstract
We propose to synthesize and study novel scintillation nanoparticles for use in a relatively new biomedical application termed photodynamic therapy (PDT). Scintillation nanoparticles can emit visible light following excitation by high-energy photons such as X-rays. The emitted visible photon can then activate a photosensitizer which produces singlet oxygen for cancer cell destruction. Therefore, this treatment can work in conjunction with traditional radiation treatments, resulting in potentially lower radiation doses to the patient. The success of such an application depends strongly on the dynamics of energy transfer from the host, to dopant, and from dopant to the photosensitizer. The energy transfer dynamics, properties of the excited states involved, and production of singlet oxygen in this process will be monitored using fluorescence and fluorescence lifetime spectroscopy.
Project Details
Project type
Large-Scale EMSL Research
Start Date
2008-08-12
End Date
2010-09-30
Status
Closed
Released Data Link
Team
Principal Investigator
Related Publications
Woo BK, AG Joly, and W Chen. 2011. "Observation of green emission from Ce3+ doped gadolinium oxide nanoparticles." Journal of Luminescence 131(1):49-53.
Yao M, AG Joly, and W Chen. 2010. "Formation and Luminescence Phenomena of LaF3:Ce3+ Nanoparticles and Lanthanide-Organic Compounds in Dimethyl Sulfoxide." Journal of Physical Chemistry C 114(2):826-831. doi:10.1021/jp9092173
Yao M, Y Li, M Hossu, AG Joly, Z Liu, Z Liu, and W Chen. 2011. "Luminescence of Lanthanide-Dimethyl Sulfoxide Compound Solutions." Journal of Physical Chemistry B 115(30):9352-9359. doi:10.1021/jp202350p