Metabolomic Markers for Low Dose Radiation
EMSL Project ID
48045
Abstract
Understanding how human organs respond to ionizing radiation (IR) at a systems biology level and identifying biomarkers for IR exposure at low doses can help provide a scientific basis for establishing radiation protection standards. Little is known regarding the physiological responses to IR at the metabolite level, which represents the end-point of biochemical processes inside cells. Our goal is to develop a reliable panel of metabolite markers for low dose radiation exposure and use them as basis for establishing radiation protection standards, with these markers thoroughly validated using in-vitro human skin models and ultimately on human population, and the biochemical mechanism of the radiological effects of these markers being comprehensively understood. Low Dose Metabolomics is one of the projects in the DOE funded low dose radiation Specific Focus Area. In order to successfully accomplish this goal, using of the mass spectrometry based capabilities in metabolite/lipids separation, characterization, and quantification is critically needed.
Project Details
Start Date
2013-04-24
End Date
2015-09-30
Status
Closed
Released Data Link
Team
Principal Investigator
Related Publications
Zhang Q, MM Matzke, AA Schepmoes, RJ Moore, BJM Webb-Robertson, Z Hu, ME Monroe, W Qian, RD Smith, and WF Morgan. 2014. "High and Low Doses of Ionizing Radiation Induce Different Secretome Profiles in a Human Skin Model." PLoS One 9(3):Article No. e92332. doi:10.1371/journal.pone.0092332