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Optimizing Oil Production in Oleaginous Yeast by Cell-Wide Measurements and Genome-Based Models


EMSL Project ID
48167

Abstract

The team at PNNL is using a combination of flow cytometry, microscopy and lipidomics to establish baseline cell biological and metabolite data on lipid production by the W29 strain of Yarrowia lipolytica. It is important to understand the context of lipid production at both cell biological (for example, compartmentalization of reactions) and metabolite levels as both are important considerations for engineering and modeling of improved strains.

Project Details

Start Date
2013-11-25
End Date
2014-09-30
Status
Closed

Team

Principal Investigator

Scott Baker
Institution
Environmental Molecular Sciences Laboratory

Co-Investigator(s)

Galya Orr
Institution
Environmental Molecular Sciences Laboratory

Team Members

Kyle Pomraning
Institution
Pacific Northwest National Laboratory

Young-Mo Kim
Institution
Pacific Northwest National Laboratory

Thomas Metz
Institution
Pacific Northwest National Laboratory

Related Publications

Pomraning KR, S Wei, SA Karagiosis, YM Kim, A Dohnalkova, BW Arey, EL Bredeweg, G Orr, TO Metz, and SE Baker. 2015. "Comprehensive metabolomic, lipidomic and microscopic profiling of Yarrowia lipolytica during lipid accumulation identifies targets for increased lipogenesis." PLoS One 10(4):e0123188. doi:10.1371/journal.pone.0123188