Two-Photon Fluorescence Measurements of Hydrogen Polysulfides
EMSL Project ID
48706
Abstract
Hydrogen polysulfides are recently confirmed signaling molecules that play important roles in sulfur-related redox biology. Nevertheless a number of fundamental issues are to be addressed to advance our understanding of the biology and clinical potential of hydrogen polysulfides. In this regard, research tools for accurate and convenient detection of hydrogen polysulfides are eagerly needed. In this proposal we plan to design, synthesize, and test a series of two-photon fluorescent probes. We plan to use the two-photon fluorescence microscope at EMSL/PNNL to validate the properties of the probes.Note: this is a request for rapid access.
Project Details
Project type
Limited Scope
Start Date
2014-12-30
End Date
2015-02-16
Status
Closed
Released Data Link
Team
Principal Investigator
Related Publications
Chen W, EW Rosser, D Zhang, W Shi, Y Li, WJ Dong, H Ma, D Hu, and M Xian. 2015. "A Specific Nucleophilic Ring-Opening Reaction of Aziridines as a Unique Platform for the Construction of Hydrogen Polysulfides Sensors." Organic Letters. doi:10.1021/acs.orglett.5b01194