Determining the Metabolome and Lipidome of Amniotic Fluid Across Gestation
EMSL Project ID
60947
Abstract
The existing literature suggests that the composition of AF is dynamic and changes across gestation. It is rich in proteins, lipids, oligosaccharides, RNAs, and metabolites that potentially influence fetal development through bioactivities11, and AF proteins and metabolites from human cross-sectional samples appear to evolve over the course of pregnancy. Alterations between different trimesters, however, have not been confirmed within the same pregnancy because serial AF sampling within the same pregnancy is not feasible in humans. Our scientific premise is that the composition of this environment, where content and volume change dynamically acrossgestation, is a key determinant of fetal health and development.
Project Details
Start Date
2023-06-23
End Date
N/A
Status
Active
Released Data Link
Team
Principal Investigator
Team Members