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Heather Olson

Institution
Environmental Molecular Sciences Laboratory
ORCID
ORCID logo 0000-0002-4501-9587

Projects

Determining the Metabolome and Lipidome of Amniotic Fluid Across Gestation

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Chaevien Clendinen
The existing literature suggests that the composition of AF is dynamic and changes across gestation. It is rich in proteins, lipids, oligosaccharides, RNAs, and metabolites that potentially influence…

Pentosan Polysulfate Sodium Profiling with Mass Spectrometry

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
John Cort
PPS is a semisynthetic heterogeneous sulfated polysaccharide derived from xylan, the β-1,4-linked polymer of xylose that is the backbone structural component of hemicellulose in most types of wood…

Multi-Scale Multi-Modality High Resolution Mapping of the Adult Human Lung

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Christopher Anderton
The Human Biomolecular Atlas Program (HuBMAP) is entering the production phase, with an emphasis on progressive, high sensitivity and specificity assays, prioritizing spatial biomolecular analysis…

Pentosan Polysulfate Sodium Profiling with Mass Spectrometry

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
John Cort
PPS is a semisynthetic heterogeneous sulfated polysaccharide derived from xylan, the β-1,4-linked polymer of xylose that is the backbone structural component of hemicellulose in most types of wood…

Proteomic study of Transthyretin Protein

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Ljiljana Pasa-Tolic
The project will establish a scientific partnership between the cardiomyopathy section at OHSU and mass spectrometry facility at PNNL which leverages the strengths of OHSU Cardiomyopathy center …

High Resolution and Mass Accuracy Capability (HRMAC) Development Project

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
David Koppenaal
Access to other FTMS instrumentation is important o successfully and rapidly implement first science applications, to facilitate parallel testing of spectrometer subsystems, and to perform cross…

Metabolic regulation of O-GlcNAc and cardiac function during hypertrophy

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Ljiljana Pasa-Tolic
Despite treatment advances, half of patients suffering from heart failure die within five years of diagnosis, while those who survive may live with severe disabilities. Cardiac hypertrophy poses a…

Metabolic regulation of O-GlcNAc and cardiac function during hypertrophy

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Ljiljana Pasa-Tolic
Despite treatment advances, half of patients suffering from heart failure die within five years of diagnosis, while those who survive may live with severe disabilities. Cardiac hypertrophy poses a…

Discovery of Host Proteins Involved in Host-Pathogen Interactions

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
The multiple mechanisms by which pathogenic enterobacteria of the genus Salmonella infect their host indicate a complex host-pathogen relationship. The pathogen secretes dozens of proteins, termed &…

Metabolic Landscape of the Aging Lung

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jennifer Kyle
Aging is a major risk factor for the majority of acute and chronic diseases of the lung, including emphysema, pulmonary fibrosis, and lower respiratory tract infections. In this study we will…

Impact of apolipoprotein E isoforms on brain lipoproteins

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
John Melchior
Cerebrovascular dysfunction leads to the deposition of amyloid plaques and neurofibrillary tangles in the brain which underlie the development of Alzheimer’s disease (AD); an epidemic that…

Developing an automation-ready high throughput chemoproteomic workflow

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Vivian Lin
We propose to develop a high-throughput (HTP) workflow for activity-based protein profiling (ABPP) or bioorthogonal non-canonical amino acid tagging (BONCAT) samples. This HTP chemoproteomic sample…

Identifying Targets for Therapeutic Interventions using Proteomic Technology

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
Project type
Exploratory Research
This proposal will utilize new comprehensive and quantitative proteomic technologies and related capabilities developed at PNNL to identify targets for therapeutic intervention for Salmonella…

Discovery of Host Proteins Involved in Host-Pathogen Interactions

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Joshua Adkins
The multiple mechanisms by which pathogenic enterobacteria of the genus Salmonella infect their host indicate a complex host-pathogen relationship. The pathogen secretes dozens of proteins, termed &…

High Resolution and Mass Accuracy Capability (HRMAC) Development Project

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
David Koppenaal
Access to other FTMS instrumentation is important o successfully and rapidly implement first science applications, to facilitate parallel testing of spectrometer subsystems, and to perform cross…

Collaborative Research Projects Supported by the NCRR P41 Resource Center

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Camp
Project type
Large-Scale EMSL Research
The Proteomics Resource Center for Integrative Biology at PNNL was established in 2003 and builds on the unique instrumentation and the infrastructure provided by PNNLs EMSL facility. The mission of…