Nanomaterial toxicology
EMSL Project ID
8493
Abstract
The immense excitement created by the developing ability to manipulate many physical and chemical properties of nanoscale objects also raises question of nanomaterial toxicity. In contrast to well-developed approaches and protocols for studies involving larger particles, the characterization, preparation, and monitoring elements of an inhalation toxicology study using nanomaterials raises new materials preparation, measurement, distribution and monitoring challenges. This section outlines important issues inherent to toxicology studies involving nanoscale materials and summarizes the approaches we have been developing to meet these challenges. Appropriate characterization of nanomaterials prior to preparation in a form suitable for an inhalation study is a challenging but probably achievable task using an appropriate mix of current methods and technology, though challenges remain in understanding and monitoring the diverse chemical and physical properties that would evolve during the course of a study. The preparation of nanomaterials in a form suitable for inhalation remains a challenge subject to ongoing effort, while real-time analysis capabilities for inhalation-ready nanomaterials will require additional development as well.
Project Details
Project type
Exploratory Research
Start Date
2004-05-03
End Date
2007-01-19
Status
Closed
Released Data Link
Team
Principal Investigator
Related Publications
Baer DR. 2011. "Surface Characterization of Nanoparticles: Critical Needs and Significant Challenges." Journal of Surface Analysis 17(3):163-169.
Baer D.R. 2018. "The Chameleon Effect: characterization challenges due to the variability of nanoparticles and their surfaces." Frontiers in Chemistry 6. PNNL-SA-131780. doi:10.3389/fchem.2018.00145