Projects

Characterization of Chelsea Humic Acid and Lanchine Kerogen by Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Lead Institution

California Institute of Technology

Principal Investigator

Mamadou Diallo

Project type

Exploratory Research

The primary objective of this research is to develop a molecular level understanding of the uptake of hydrophobic organic compounds by CHA and LK. To achieve this objective, we propose to implement…

Characterization of Bacteriophage T4 Early Gene Proteins

Lead Institution

The Evergreen State College

Principal Investigator

James Neitzel

Project type

Exploratory Research

We have cloned and are purifying a number of early genes from bacteriophage T4. These gene products are usually lethal to E. coli, and in comparison with sequence data bases they have no obvious…

Characterization of Novel Charge Ladders by Capillary Electrophoresis-FTICR Mass Spectrometry

Lead Institution

Harvard University

Principal Investigator

George Whitesides

Project type

Exploratory Research

We believe that CE-ESI-FTICR-MS will be important in the characterization of complex charge ladders of proteins and aminoglycosides. The reaction of Lys- -NH2 groups of bovine carbonic anhydrase II …

Quantifying Human Liver Alcohol Dehydrogenase Isoenzymes

Lead Institution

Stevens Institute of Technology

Principal Investigator

Carol Stone

Project type

Exploratory Research

Researchers report individual variation in ethanol elimination, both within and between ethnic groups, as well as between gender groups. The human alcohol dehydrogenase isoenzymes expressed in liver…

MS Verification of Non Covalent Heterodimer Complex BRAC1-BARD1 Za Binding Sites

Lead Institution

University of Washington

Principal Investigator

Rachel Klevit

Project type

Exploratory Research

The next stage in structure determination of the BRCA1-BARD1 heterodimer complex requires the assignment of aliphatic side chain H-1 and C-13 resonances. Typically, HCCH-TOCSY experiments on fully…

Investigation of Tandem Mass Spectrometry for Identifying Single and Mass-Compensating Double Base Substitutions in p53 and Bacterial Ribosomal PCR Products

Lead Institution

University of South Carolina School of Medicine

Principal Investigator

Alvin Fox

Project type

Exploratory Research

The p53 gene has been recognized in the past few years as an important cell cycle regulatory gene implicated in the production of cancers. One form of the altered gene implicated in cancers…

Characterization of Gold Nanoparticles by FTICR MS/MS

Lead Institution

University of North Carolina

Principal Investigator

Allen Templeton

Project type

Exploratory Research

Gold nano particles have become the subject of great interest due to their unique physical properties which lend them to a wide variety of potential applications such as sensors, optical switches,…

Global and Targeted Proteomic Identification of oxidative modifications.

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Diana Bigelow

Project type

Exploratory Research

Recent research has provided an emerging picture of the significant role of reactive oxygen/nitrogen species (ROS/RNS) and their associated modification of cellular proteins in cellular signaling…

Evaluation of Pore scale porous media effects on reactive transport in groundwater

Lead Institution

University of Texas at Austin

Principal Investigator

Charles Werth

Project type

Exploratory Research

We request use of the EMSL Subsurface Flow and Transport Laboratory?s syringe pumps and work space in order for Thomas Willingham to complete the experimental phase of his Doctoral Research…

TGA Analysis of Synthesized Organic Components of Self-assempbled Monolayers on Mesoporous Silica.

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Robert Wiacek

Project type

Exploratory Research

Nanostructured materials, such as mesoporous silica, may be imparted with desired chemical selectivity and functionality through the use of attached organic functional groups. However, verification…

The use of FESEM

Lead Institution

University of South Carolina

Principal Investigator

Xiao-dong Zhou

Project type

Exploratory Research

It is the intent of this proposal to apply for the access of FESEM. FESEM will be used to characterize the grain size, film thickness and surface morphology of thin films, which are fabricated at…

Ion Beam Modification of Advanced Titanium Alloys

Lead Institution

Colorado School of Mines

Principal Investigator

Kip Findley

Project type

Exploratory Research

The Navy is constantly seeking new materials or new processing methods to improve the life of components used in underwater structural applications such as submarines and ships. Advanced titanium…

Control of Hydrogen Release and Uptake in Condensed Phases (Scope #48587)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Autrey

Project type

Exploratory Research

Theoretical and experimental methods will be used to study hydrogen release and uptake from selected hydrogen-rich materials. Hydrogen-rich materials deposited in mesoporous templates will be…

Center of Excellence for Chemical Hydrogen Storage (scope #46385)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Autrey

Project type

Exploratory Research

Characterization of novel materials and the measurement of enthalpy of reaction and determination of activation barriers, determination of thermodynamics of substituted compounds, synthesis of B,N,C…

Personal Samplers for Traffic-Related Particle Exposures in NYC

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

James Cowin

Project type

Exploratory Research

The goal is to develop and test air samplers for personal use that are smaller, quieter, "smarter" (see below), and longer-lived (10 to 100 days) than currently available. To be monitored…

Technetium (Tc) reduction by chemically and biologically reduced smectite clay

Lead Institution

Miami University

Principal Investigator

Hailiang Dong

Project type

Exploratory Research

Oxidized form of technetium (Tc7+) is highly toxic and soluble when they are present in water systems(1). Large quantities of these radioactive heavy metals are released from storage tanks of…

Cerebrospinal Fluid Proteome

Lead Institution

University of Medicine and Dentistry, New Jersey Medical School

Principal Investigator

Steven Schutzer

Project type

Exploratory Research

The exact cause of many neurologic diseases remains unknown. Consequently there are no effective treatments. The cerebrospinal fluid (CSF) is a liquid extension of the brain and is likely to contain…

Applications of Nanostructured materials and electrodes in Electrochemical sensors and fuel cell

Lead Institution

Fudan University

Principal Investigator

Xiaoli Cui

Project type

Exploratory Research

Nanostructured materials and electrodes will be designed and constructed and their application researches in electrochemical sensors and fuel cell will be studied. The nanostructured materials…

Determination of elemental distribution within catalyst pat;icles prepared by various procedures.

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

John Frye

Project type

Exploratory Research

Use SEM and/or TEM to determine how various elements, constituting active and passive catalyst components are distributed throughout various heterogeneous catalyst supports. The catalysts will be of…

Plasma Functionalization of electroactive polymers

Lead Institution

Novellus

Principal Investigator

Johanes Sukamto

Project type

Exploratory Research

The proposed research will provide the basis for using electroactive ion exchange materials to remove anionic contaminants from HLW wastes and process streams. An ion exchange process using…