Projects

Characterization of Chemical Changes Observed for Uranium Particulate Materials

Lead Institution

Savannah River National Laboratory

Principal Investigator

Glenn Fugate

Project type

Exploratory Research

Small uranium particulates emanating from nuclear fuel cycle and weaponization processes can be collected at significant distances from their source. The chemical and physical characteristics of…

Investigation of Surface Coating on High Voltage Lithium Ion Cathode Materials Using Combined TEM and Atom Probe Tomography

Lead Institution

University of California, San Diego

Principal Investigator

Ying Meng

Project type

Exploratory Research

Lithium ion batteries are the top candidates for on-board energy storage in plug-in hybrid electric vehicles (PHEV) and fully electric vehicles due to a higher energy density and rate capability…

Multilayered Metal/Ceramic Composites for Structural Materials Application

Lead Institution

Rensselaer Polytechnic Institute

Principal Investigator

Jie Lian

Project type

Exploratory Research

The design of structural materials for advanced nuclear materials is limited within a window confined by radiation-induced embrittlement at low temperature and creep rupture at high temperature…

Characterization of Surface, Interfacial, and Bulk Phenomena for Next Generation Electronic Systems

Lead Institution

Oregon State University

Principal Investigator

Gregory Herman

Project type

Exploratory Research

This project aims to improve the fundamental understanding of materials, chemistries, and interfacial phenomena for novel electronic devices and systems. Our initial efforts focus on the synthesis,…

Probing the Selective Action of Cerium Oxide in Cancer and Normal Cells

Lead Institution

University of Central Florida

Principal Investigator

Sudipta Seal

Project type

Exploratory Research

There is an imminent need to determine the mechanisms that define the interaction of nanomaterials with biological systems. Several nanomaterials show unique and perplexing characteristics in…

Polarization-Induced Interfacial Reactions between Nickel and Sulfur in Fuel Cell Electrodes and Mitigation of Sulfur Poisoning via Ni Surface Modification

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Olga Marina

Project type

Exploratory Research

The purpose of this project is 1) to gain understanding how the electrode chemistry is affected by exposure to fuel gas impurities under polarization, and 2) how to efficiently minimize the negative…

Interfacial Investigations of Nuclear Waste Forms

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joseph Ryan

Project type

Exploratory Research

EMSL resources are requested to enable an international team of collaborators to solve fundamental problems in interfacial glass corrosion chemistry. With the recent dismissal of Yucca Mountain as…

Advanced microstructural analysis of environmental degradation using site-specific transmission electron microscopy and atom-probe tomography

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Daniel Schreiber

Project type

Exploratory Research

Environmental degradation of Ni-based alloys continues to be a major problem in high-temperature water environments such as those found in nuclear reactors and steam generators. Despite several…

Probing Mechanical Deformation and Evolution of Physical/Chemical Properties in High Capacity Li Battery Materials during Electrochemical Cycling Using In-Situ TEM

Lead Institution

Stanford University

Principal Investigator

Yi Cui

Project type

Exploratory Research

The goal of this work is to probe electrochemical transformations in next-generation Li-ion battery materials in-situ to correlate morphology, structural changes, and physical degradation to…

Investigation of Surface/Interface Structure and Chemistry of Tungsten-Based Oxides and Oxynitrides

Lead Institution

University of Texas at El Paso

Principal Investigator

Chintalapalle Ramana

Project type

Exploratory Research

The focus of the present project is on the tungsten (W) based oxide and oxynitride thin-films, which will have numerous applications in energy conversion and utilization technologies. The goal of the…

Characterization of Catalyst Materials in the Electron and Atom Probe Microscopes

Lead Institution

Argonne National Laboratory

Principal Investigator

Ilke Arslan

Project type

Exploratory Research

The aim of this proposal is to combine existing techniques in the electron and atom-probe microscopes to afford novel methods for a fundamental understanding of catalyst interactions with atomic…

Unraveling Oxygen Reduction Reaction at Solid Oxide Fuel Cell Cathodes

Lead Institution

Boston University

Principal Investigator

Srikanth Gopalan

Project type

Exploratory Research

We seek to uncover the role of the structure and chemistry of the surfaces of solid oxide fuel cell cathodes in the oxygen reduction reaction. In particular we seek to understand the relationship of…

Cardiac Metabolism and Protein Synthesis during Extracorporeal Life Support

Lead Institution

Seattle Children's Research Institute

Principal Investigator

Michael Portman

Project type

Exploratory Research

Mechanical Circulatory Support (MCS) in the form of cardiopulmonary bypass (CPB) is commonly used for infants and children. Extracorporeal life support (ECLS) also a form of MCS remains the primary…

Global Analysis of Histone Post-translational Modifications Specific to Rett Syndrome using 2D RPLC/WCX-HILIC for Online Top-down Mass Spectrometry

Lead Institution

University of Edinburgh

Principal Investigator

Patrick Langridge-Smith

Project type

Exploratory Research

Epigenetics is a rapidly expanding field in biology, due to many technological breakthroughs and a greater understanding of the mechanisms of gene regulation. The location of epigenetic markers such…

Carbon Nanotube-Intestinal Barrier Cell Interactions, Absorption, and Dosimetry

Lead Institution

Indiana University School of Medicine

Principal Investigator

Frank Witzmann

Project type

Exploratory Research

Carbon nanotubes (CNT) are important components of the rapidly expanding nanotechnology field. Due to their size and unique chemical, electrical, mechanical, and thermal properties, they have found…

Electron-Acceptor Fullerene Materials for Organic Photovoltaics: Electronic Properties in Gas-Phase, Solution, Solid-Phase and in Donor/Acceptor Blends

Lead Institution

Colorado State University

Principal Investigator

Steven Strauss

Project type

Exploratory Research

This project will focus on understanding of the fundamental relationships between molecular structures of perfluoroalkylated fullerenes (PFAFs) and their electronic properties in the gas-phase, in…

An integrated top-down / bottom-up method to identify disease related antibodies

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Theo Luider

Project type

Exploratory Research

We describe the discovery of a new class of biomarkers derived from immunoglobulins using mass spectrometry. We previously investigated this approach in model systems with bottom-up proteomics, and…

Comparative analysis of the Mosquito Vector and Vertebrate Host of Dengue Virus: Characterizing the Membrane Structures Required for Virus Replication

Lead Institution

Purdue University

Principal Investigator

Rushika Perera

Project type

Exploratory Research

This proposal is submitted in response to EMSL's science theme "Biological Interactions and dynamics." Our objective is to use high-resolution mass spectrometry and time-lapse single…

Leveraging rRNA pseudouridylation defects to identify operational programmed -1 ribosomal frameshift signals in yeast, mice and human cells.

Lead Institution

University of Maryland, College Park

Principal Investigator

Jonathan Dinman

Project type

Exploratory Research

Programmed -1 ribosomal frameshifting (-1 PRF) is a molecular mechanism in which cis-acting signals direct a fraction of elongating ribosomes to slip by 1 nucleotide in the 5-prime direction along an…

Mesocrystalline Positive Electrode Materials for Lithium-Ion Battery

Lead Institution

University of Washington

Principal Investigator

Guozhong Cao

Project type

Exploratory Research

The applied use of nanoparticles has been the subject of intense research over the past several decades due to the novel properties and tunable functions of nanoparticles that can be utilized in a…