Projects

Interactions Between Domains in Dematin, a Key Component of the Red Blood Cell Junctional Complex.

Lead Institution

Boston University School of Medicine

Principal Investigator

Christopher Mcknight

Project type

Large-Scale EMSL Research

The regulation and maintenance of the actin cytoskeleton is essential for all eukaryotic cells. The "villin-type headpiece" family of actin-associated proteins contains a modular C…

Tuning the chemistry and configuration of oxide nanostructures for energy and environmental applications

Lead Institution

University of Central Florida

Principal Investigator

Sudipta Seal

Project type

Large-Scale EMSL Research

Materials development based on a fundamental understanding of their behavior has gained a new impetus with the advent of nanotechnology. Oxide nanostructures are among the most widely studied…

Neuropeptides and vasoactive protein detection from human skin.

Lead Institution

University of Oregon

Principal Investigator

Christopher Minson

Project type

Large-Scale EMSL Research

I am submitting this proposal through the EMSL Science Theme Call: Biological Interactions and Dynamics. The overarching goal of this proposal is to develop novel approaches to recover and identify…

Morphology of colloids formed in soils reacted with simulated Hanford Waste Tank solutions and the distribution of incorporated and adsorbed cesium in the colloids

Lead Institution

Washington State University

Principal Investigator

Youjun Deng

Project type

Exploratory Research

High-level radioactive waste solutions stored in the underground tanks at Hanford sites have leaked into the vadose zone. The waste tank supernatants are known to consist of solutions with high pH (9…

Integrated NMR/SIP technologies for the functional and structural characterization of microbial communities

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Johannes Scholten

Project type

Large-Scale EMSL Research

We propose to combine stable isotope probing (SIP) of DNA (SIP-DNA) with real-time on-line SIP-nuclear magnetic resonance (SIP-NMR) analysis of microbial community metabolism. SIP-NMR provides access…

Imaging Respiratory Structure and Function In Laboratory Animals

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kevin Minard

Project type

Large-Scale EMSL Research

The goal for this NIH-funded project is to develop Magnetic Resonance (MR) imaging for visualizing - 1) airway architecture, 2) lung mechanics, 3) gas flow, and 4) particulate deposition in live…

Microscale and spectroscopic investigations in geochemical and microbiological systems

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

John Zachara

Project type

Large-Scale EMSL Research

Apply experimental manipulation and field investigations to understanding the behavior of selected chemical and microbial components in natural systems. The research is targeted towards compounds…

MRI of chronic obstructive pulmonary disease

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kevin Minard

Project type

Large-Scale EMSL Research

Proposed work will be performed using normal rats and emphysematous counterparts. The specific aims are to - 1) quantify regional alveolar airway destruction in vivo using 19F gas MRI techniques…

COMBINED NMR/OPTICAL MICROSCOPY OF BIOFILM PHYSIOLOGY STUDIES

Lead Institution

Washington State University

Principal Investigator

Paul Majors

Project type

Large-Scale EMSL Research

Bacterial biofilms are found nearly everywhere in nature. Microbial metabolism and phenotype vary rapidly within a biofilm - this is at least partly responsible for their metabolic diversity and…

Fundamental understanding of charge transfer from a Ru-based dye adsorbate to a TiO2(110) surface

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Michael Henderson

Project type

Large-Scale EMSL Research

Ru-based dye-sensitized TiO2 solar cells have attracted significant attention because of their potential use in photovoltaic cells[1,2]. These devices utilize films of optically transparent TiO2…

Bradley Tebo's Proposal

Lead Institution

University of Washington

Principal Investigator

Bradley Tebo

Project type

Large-Scale EMSL Research

Mn oxides are important mineral phases in a variety of environments and have potential application in solar energy capture and conversion and contaminant remediation technologies. In nature,…

Integrated Experimental and Modeling Studies on Aerosol Evolution and Aging

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Rahul Zaveri

Project type

Large-Scale EMSL Research

The objectives of this project are to characterize the time evolution of aerosol size, density, composition, and mixing state in an aerosol chamber, and b) link experiments to the development and…

Ionic Transport of Hydrogen in Structured Soft Materials

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

James Cowin

Project type

Large-Scale EMSL Research

We will explore how the motion of hydrogen in the form of hydronium is controlled in a nanometer-sculpted multilayer composite water/hydrocarbon film, and how the motion of the ion alters the…

Cryo-TEM investigation of polyketide synthase megacomplexes in Candidatus Endobugula sertula and Teredinibacter turnerae

Lead Institution

Oregon Health & Science University

Principal Investigator

Margo Haygood

Project type

Large-Scale EMSL Research

This Biological and Life Sciences, Biological Interactions and Interfaces Theme, Standard, General, Non-Proprietary project proposal for use of the EMSL cryo-TEM and tomography facility will focus on…

Imaging Of Water and Gas Distribution in PEM Fuel Cell Stacks and Cells

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kevin Minard

Project type

Large-Scale EMSL Research

The overall objective of this project is to develop three-dimensional magnetic resonance imaging (MRI) for in-situ, real-time monitoring of polymer electrolyte membrane (PEM) fuel cell…

Benchmark modeling of aerosol-cloud interactions

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Konstantin Ovchinnikov

Project type

Large-Scale EMSL Research

This proposal requests computing resources from the Molecular Science Computation Facilities (MSCF) to support two projects of the PNNL Aerosol-Climate Initiative: "Benchmark Modeling of the…

Experimental Investigation of Strontium Mass Transfer in a Dynamic Vadose Zone - Aquifer - River System

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Steven Yabusaki

Project type

Large-Scale EMSL Research

At a number of DOE sites, groundwater flowing through contaminated sediments before discharging to a river is being relied on to meet regulatory standards. This natural flushing (i.e., monitored…

Development of a Scalable Solution-based Catalyst Fabrication Process using Microreaction Technology

Lead Institution

Oregon State University

Principal Investigator

Chih-hung Chang

Project type

Large-Scale EMSL Research

Nanoscale heterogeneous catalysts require structural control over several scales of dimensions. A rigorous approach is to use a combination of physical vapor deposition (e.g. molecular beam epitaxy,…

Terrestrial Carbon Sequestration Studies

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

James Amonette

Project type

Large-Scale EMSL Research

One of the approaches to minimizing the possible effects of climate change stemming from the recent increases in atmospheric CO2 levels involves storing C as biomass in terrestrial ecosystems. Of…

Structural investigation of human small heat shock proteins alpha-beta-crystallin and HSP27.

Lead Institution

University of Washington

Principal Investigator

Rachel Klevit

Project type

Large-Scale EMSL Research

In response to stress, the family of proteins known collectively as small heat shock proteins (sHsp) may comprise as much as 1% of the total cellular protein. Found in all organisms from bacteria to…