Projects

As a scientific user facility, the Environmental Molecular Sciences Laboratory (EMSL) provides expertise, instrumentation, and resources to 250 projects each year.

EMSL projects displayed on the EMSL web site project page reflect project abstracts and information migrated to this page before April 30, 2024. To review current and past EMSL user projects, visit EMSL Science Central.™

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Metz

This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…

Comprehensive comparison of taxonomic composition and metabolic functioning in oxygenic and anoxygenic microbial mats of Yellowstone hot springs

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Metz

This proposal focuses on comparing a rare, but evolutionarily important, modern laminated microbial mat formed exclusively by anoxygenic photosynthetic microorganisms and a well-studied mat formed by…

Pacific Northwest Advanced Compound Identification Core

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Metz

The capability to chemically identify thousands of metabolites and other chemicals in clinical samples will revolutionize the search for environmental, dietary, and metabolic determinants of disease…

Pentosan Polysulfate Sodium Profiling with Ion Mobility Mass Spectrometry

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

John Cort

Pentosan polysulfate sodium, known as PPS, is the active pharmaceutical ingredient in the prescription drug Elmiron, and is indicated for interstitial cystitis, a painful bladder condition caused by…

EMERGING VIRUS-HOST CELL PROTEIN INTERACTION NETWORKS

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Ernesto Nakayasu

The overall goal of this proposal is to identify and characterize cellular proteins that bind to viral hemorrhagic fever viruses. Specifically, we focus on RNA viruses from four families: the…

Electrochemical 19F Labelling of Technical Lignin for Enhanced NMR Analysis

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Robert Young

Nuclear Magnetic Resonance (NMR) is a powerful tool to analyze the structure of lignin, however the complexity of this natural mixture hinders interpretation due to substantial signal overlap in…

Conformational changes in Rag GTPases orchestrate signaling activities of mTORC1

Lead Institution

Whitehead Institute

Principal Investigator

David Sabatini

The mTORC1 protein kinase is a growth regulator that responds to stimuli, including nutrients and growth factors. Amino acids promote its translocation to the lysosomal surface, where it interacts…

Magnetic Resonance Microscopy of Water Dynamics at Hydrophilic Surfaces

Lead Institution

University of Washington

Principal Investigator

Gerald Pollack

Project type

Capability Research

Recent work at the University of Washington shows that suspended solutes are excluded from water within ~100 microns of hydrophilic surfaces. One possible hypothesis for this is that hydrophilic…

Software Development for High-Resolution Mass Spectrometry Analysis of Small Molecules: Enabling High-Throughput, Reproducible Data Processing and Annotation.

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Yuri Eberlim de Corilo

Modern high-resolution mass spectrometry has dramatically increased the volume (distinct analytical techniques and polarity modes) and quality (higher resolving power, dynamic range, mass error…

Development and Implementation of Online Separation Techniques Coupled to Native Mass Spectrometry for Characterization of Endogenous Proteins Extracted from Biological Matrices

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Mowei Zhou

Recent developments of state-of-the-art mass spectrometry (MS) instrumentation at EMSL, including the 21T Fourier Transform Ion Cyclotron Resonance (FTICR) MS, have enabled high resolution and high…

Dynamic TEM

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

James Evans

Achieving a holistic, molecular-level understanding of the structure, function and mechanism of cellular machinery remains a formidable scientific challenge. While over 100,000 protein structures…

Development of in vitro glycosylation toolkit to study eukaryotic glycoproteins

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Irina El Khoury

When working with glycoproteins from native sources, biochemical analysis is often hampered by sample heterogeneity and glycan-postprocessing structural diversity. It is therefore desirable to create…

A Multi-Omics Data Exploration and Integration Web Application

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Lisa Bramer

In the biological and environmental sciences, data are being generated at an unprecedented rate. There are many scientific discoveries pertinent to DOE missions that are waiting to emerge from high…

Development of Computational Chemistry Tools for Aerosol Chemistry and Molecular-Level Characterization of Secondary Organic Aerosol particles

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Edoardo Apra

Our project is focused on the development of advanced quantum chemistry capabilities to enable molecular level characterization of secondary organic aerosol (SOA) particles and aerosol chemistry. The…

Targeted spatial metabolomics: an automated approach to identifying and analyzing single cells in situ

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Christopher Anderton

Tissue-scale or cell-population-level analysis (i.e., ‘bulk analysis’) yields averaged abundance data that can mask critical information about the state of individual cells. Through a recently ended…

Real-Time Mass Spectrometry (RT-MS) Instrument Upgrade and Development

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Karl Weitz

EMSL currently houses the only Battelle patented real-time atmospheric sampling manifold technology that is used for monitoring in situ living systems in real-time. However, using this technology…

Application of machine learning to APT data to trace nanoscale protein structure

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Daniel Perea

The objective of this project is the development and application of deep learning algorithms aimed at extracting molecular structure within Atom Probe Tomography (APT) data collected from protein…

Deriving chemical mass spectral signatures of aqueous-phase SOA formed due to oxidation of biomass burning emissions for analysis of ASR/ARM field datasets

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

ManishKumar Shrivastava

Secondary organic aerosol (SOA) formed by multiphase chemical reactions in the atmosphere greatly contribute to fine particulate matter and organic aerosols (OA). Despite mounting evidence, aqueous-…

Chromatographic Approaches for Functional Natural Organic Matter Characterization

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kent Bloodsworth

Electrospray ionization (ESI), coupled to high resolution Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS), is the de facto standard for complex natural mixture analysis. Our…

Position-specific stable isotope analysis for elucidating provenance and fate of organic matter

Lead Institution

Michigan State University

Principal Investigator

James Moran

The EMSL 21T FTICR MS is amongst the highest mass resolution of any mass spec ever developed (> 6M at m/z 700 (Shaw et al., 2016)). We seek to provide a proof of concept that suitable stability…

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