Projects

As a scientific user facility, the Environmental Molecular Sciences Laboratory (EMSL) provides expertise, instrumentation, and resources to 250 projects each year.

EMSL projects displayed on the EMSL web site project page reflect project abstracts and information migrated to this page before April 30, 2024. To review current and past EMSL user projects, visit EMSL Science Central.™

Structural studies of a bacterial siderophore ABC importer YbtPQ

Lead Institution

University of Colorado Anschutz Medical Campus

Principal Investigator

Hongjin Zheng

Iron (Fe) is an essential element for not only the well-being of hosts, but also the growth and virulence of microbes(Begg, 2019). One of the major Fe uptake processes in bacteria is through…

Biosynthesis, assembly and secretion of cell surface polysaccharides

Lead Institution

University of Virginia

Principal Investigator

Jochen Zimmer

All forms of life produce extracellular complex carbohydrate to form cell walls, protective coats, or to define an extracellular matrix aiding in cell-to-cell communication and adhesion. Cellulose, a…

Analysis of catalysts and microchannel components

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Victoria Stenkamp

Project type

Exploratory Research

Microtechnology offers a method of process intensification for a variety of processes, including heat exchangers, reactors, and separators. In order to accompish process intensification, many…

Gaining new insights into microbial methanogenesis and anaerobic methane oxidation through in vivo nuclear magnetic resonance spectroscopy

Lead Institution

Boston University

Principal Investigator

Jeffrey Marlow

Project type

Exploratory Research

Methane is a singularly important molecule in the context of the United States' energy and environmental priorities. It represents a substantial energy source and potential feedstock for biofuel…

Exploring soil organic matter dynamics in a warming world using an array of warming experiments and soil models

Lead Institution

Rocky Mountain Biological Laboratory

Principal Investigator

Aimee Classen

Project type

Exploratory Research

Soil carbon (C) feedbacks to the atmosphere remain one of the greatest areas of uncertainty in future climate predictions, largely due to an inadequate representation of three key factors in…

Feedbacks between microbial community dynamics and the persistence of soil organic carbon

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kirsten Hofmockel

Project type

Exploratory Research

Soil organic matter (SOM) is the largest active carbon reservoir in the terrestrial environment and significantly influences soil fertility, water quality, global C cycling and associated feedbacks…

Control of climate on soil organic matter formation, sources and stabilization

Lead Institution

University of Wyoming

Principal Investigator

Mengqiang Zhu

Project type

Limited Scope

Soil organic matter (SOM) is the largest organic carbon (C) pool in terrestrial ecosystems and its formation and stability strongly affect global carbon cycling and climate change. The widely…

Vertical profile of atmospheric particle composition via tethered balloon system

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Fan Mei

Project type

Exploratory Research

The vertical distribution of aerosol strongly influences the radiative forcing of the aerosols. However, observational data is limited. Both satellite observation and ground-based measurements are…

The effects of coculture on cellular spatial heterogeneity in colony and plant-associated biofilms

Lead Institution

University of Massachusetts Medical School

Principal Investigator

Elizabeth Shank

Project type

Exploratory Research

Bacteria live everywhere, from the soil and sea to the surface of every plant and animal on earth. Most bacteria exist within diverse, multispecies communities that exert profound impacts on their…

Character of organic matter in soils of temperate forest ecosystems: Do chlorophyll catabolites (phyllobilins) travel deep?

Lead Institution

Cornell University

Principal Investigator

Carmen Martinez

Project type

Exploratory Research

Soil organic matter (SOM) is the largest reservoir of carbon (C) and nutrients, especially nitrogen (N), in terrestrial ecosystems. SOM is found throughout soil profiles, with content typically…

Structural Polymorphism of Solid Lipid Nanoparticles (LNPs) containing Natural Cholesterol Analogs

Lead Institution

Oregon State University

Principal Investigator

Gaurav Sahay

Lipid-based nanoparticles (LNPs) are the most advanced nanotherapeutics for the delivery of ribonucleic acids (RNA) for gene therapy. They are the only nanoparticles being used in the clinic for RNA…

Unravelling The Mechanisms Of Biomineralization In A Biogeochemically Significant Microbe Through Multimodal Nano-Imaging At The Organic-Inorganic Interface

Lead Institution

University of Washington

Principal Investigator

Alexander Gagnon

Project type

Exploratory Research

The pace of skeletal growth in shells and bones during biomineralization is impacted by interactions between biologically produced organic compounds and the growing mineral. The organic component…

Mineralogy and Soil Organic Matter Composition as Drivers of Reactive Nitrogen Emissions from Midwestern Hardwood Forest Soils

Lead Institution

Indiana University - Bloomington

Principal Investigator

Jonathan Raff

Project type

Exploratory Research

The overall goal of this proposal is to investigate how plant-microbe-mineral interactions drive emissions of reactive nitrogen from soils. Fluxes of reactive nitrogen oxides [NOy = NO + NO2 + HONO]…

Quantifying Peptide Abundance Ratios

Lead Institution

North Carolina State University

Principal Investigator

Michael Goshe

Project type

Exploratory Research

Regulation of protein expression and modulation of post-translational modifications (PTMs) are biochemical processes that are vital to cellular function. Phosphorylation and glycosylation are two of…

Interrogating human immune response to vaccination

Lead Institution

Duke University

Principal Investigator

Priyamvada Acharya

The goal for HIV-1 vaccine design is to induce HIV-1–reactive broadly neutralizing antibodies (bnAbs). In this study we are focused on eliciting antibodies that target the binding site of the CD4…

Mechanistic Studies of Hydrogen Addition Reactions

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Zdenek Dohnalek

This proposal focuses on attaining the mechanistic understanding of catalytic biomass hydrogenation reactions using small oxygenates as models for various functional groups present in biomass…

EDRN Biomarker Reference and Resource Center with the Department of Energy

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The purpose of the Early Detection Research Network (EDRN) Biomarker Reference and Resource Center (BRRC) is to develop a multiplex quantitative MS-based method, based on LC-SRM-MS for simultaneous…

CPTAC Proteome Characterization Center

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The overall objective of the PNNL Proteome Characterization Center (PCC) is to integrate genomic information with proteomic technologies to comprehensively characterize the proteome and post…

Proteomics Laboratory for The Environmental Determinants of Diabetes in the Young

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Metz

Type 1 diabetes mellitus (T1D) is a common autoimmune disease in children and results from autoimmune destruction of insulin-producing pancreatic ?-cells triggered by complex interactions of…

3D Flow and transport in highly heterogeneous porous media

Lead Institution

Oregon State University

Principal Investigator

Brian Wood

Project type

Exploratory Research

We will be examining flow and transport, specifically macrodispersion, in highly heterogeneous media in 3-dimensions. Particular focus will be on tailing phenomena that lead to non-Fickian spreading…

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