Projects

As a scientific user facility, the Environmental Molecular Sciences Laboratory (EMSL) provides expertise, instrumentation, and resources to 250 projects each year.

EMSL projects displayed on the EMSL web site project page reflect project abstracts and information migrated to this page before April 30, 2024. To review current and past EMSL user projects, visit EMSL Science Central.™

Cryo-EM studies of TRP channels

Lead Institution

Duke University

Principal Investigator

Seok-Yong Lee

Transient receptor potential (TRP) channels are a superfamily of calcium-permeable ion channels that are involved in diverse physiological processes. A subset of TRP channels that are known as the…

In situ TEM study of branched nanocrystal growth mechanism

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Dongsheng Li

The long-term goal of this project is to understand the growth of complex crystalline structures by aggregation and oriented attachment (OA) of primary nanoparticles and thus to tune crystal…

In situ TEM study of hierarchical nanowires growth via screw dislocation driven mechanism

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Dongsheng Li

Electrical, optical and mechanical properties of inorganic nanostructures have strong relationships with their morphologies. For example, one-dimensional (1D) nanomaterials such as carbon nanotubes,…

Synthesis and Characterization at Atomic Level of Novel Nanocrystalline Metal Oxide Structures

Lead Institution

Nanjing Normal University

Principal Investigator

Zhongqing Yu

Project type

Exploratory Research

This project will focus on two objectives: 1) controllable formation of cooper oxide (Cu2O) quantum dots (QD) using oxygen plasma assisted molecular beam epitaxy (OPA MBE); 2) analysis of grown…

Characterizing the impact of soil phosphorus on soil organic matter stabilization

Lead Institution

Ohio University

Principal Investigator

Jared DeForest

Project type

Exploratory Research

Phosphorus (P) is an essential nutrient for life, but its role in mediating important biogeochemical cycles is often overlooked or misunderstood due to the emphasis on carbon (C) and nitrogen (N)…

Biomolecular linkages between detrital inputs and soil organic matter decomposition across temperate forest regions

Lead Institution

Oregon State University

Principal Investigator

Kate Lajtha

Project type

Exploratory Research

Limited knowledge of the molecular mechanisms behind soil organic matter (SOM) stabilization and destabilization processes impedes improving models of earth systems and global carbon dynamics, as…

Medical Defenses Against Emerging Infectious Disease

Lead Institution

La Jolla Institute for Immunology

Principal Investigator

Erica Saphire

Hemorrhagic fever viruses like Ebola, Marburg, and Lassa cause up to 90% lethality. To study these re-emerging threats to human health and develop the needed vaccines and antivirals, our laboratory…

Single-Particle Microscopy of Arctic Atmospheric Particles

Lead Institution

University of Michigan

Principal Investigator

Kerri Pratt

Project type

Exploratory Research

Single-particle microscopy will be used to characterize the chemical composition of individual Arctic atmospheric particles collected during two Department of Energy Atmospheric Radiation Measurement…

Deciphering histone codes underlying diurnal and cell cycle state transitions in Chlamydomonas

Lead Institution

Donald Danforth Plant Science Center

Principal Investigator

James Umen

Project type

Exploratory Research

The long-term goal of this project is to understand the dynamic genetic programming which underlies cell growth and proliferation in green algae. Proliferating microalgae in a diurnal environment are…

Understanding the role of ice nucleating particles for heterogeneous ice formation in atmospheric clouds

Lead Institution

Colgate University

Principal Investigator

Eric Muller

Project type

Exploratory Research

Atmospheric ice nucleation affects cloud radiative properties, lifetime and precipitation behavior with far-reaching implications for global climate. While homogeneous freezing of water droplets only…

Ultra-High Resolution Ion Mobility-Mass Spectrometry Metabolomics Platform

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Yehia Ibrahim

Metabolomics is increasingly utilized and essential to biomedical research and has broad potential applications extending to the clinic. This potential is inhibited by the limitations of current…

Targeting the PP2A phosphatome with structure-based drug design and a selective heterotrimeric binding pocket.

Lead Institution

Case Western Reserve University

Principal Investigator

Derek Taylor

A major serine/threonine phosphatase, Protein Phosphatase 2A (PP2A), is responsible for the majority of cellular phosphatase activity under physiologic conditions and is dysregulated in an array of…

Understanding the evolution of the coat protein fold using P22-like phages

Lead Institution

University of Connecticut

Principal Investigator

Carolyn Teschke

Despite very low sequence homology, the major capsid proteins of dsDNA bacteriophages, some archaeal viruses and the herpesviruses, share a common structural motif - the HK97-fold. My group is…

Spotlight on microbial interactions leading to biofouling of landfill methane collection systems

Lead Institution

University of Waterloo

Principal Investigator

Laura Hug

Project type

Exploratory Research

Biofilm is the dominant life strategy for microorganisms in environments from pristine aquifers to engineered systems. Biofilm provides structure, protection, and an opportunity for tightly-knit…

Probing the mechanism of COR2R hydrogenation over Co and Fe single nanoparticles: Route to nanoparticle structural intimacy by Atom Probe Tomography

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Daniel Perea

Addressing the negative impact of COR2R on the global environment requires a multifaceted mitigation strategy which includes COR2R conversion to higher value compounds, satisfying both economic and…

Use of In Situ NMR and EPR to observe and identify active species in peracetic acid-catalyzed lignin oxidation

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Mariefel Olarte

This proposal aims to identify the active species from peracetic acid that are involved in the oxidative depolymerization of lignin. Results from this study will inform other efforts to identify…

Dissecting the central metabolic network of Aspergillus niger during growth on plant biomass

Lead Institution

Westerdijk Fungal Biodiversity Institute

Principal Investigator

Ronald de Vries

Project type

Exploratory Research

Sugar conversion through central carbon catabolism in filamentous fungi is a complex progress that involves many pathways. Using the high quality manually curated genome sequence of Aspergillus niger…

Exploratory study to determine the spatial and temporal transcriptional landscape of the Sorghum bicolor stem

Lead Institution

University of Illinois at Urbana-Champaign

Principal Investigator

Amy Marshall-Colon

Project type

Exploratory Research

Sorghum bicolor is an important bioenergy crop because it has high nutrient and water use efficiency, and produces a large quantity of biomass that can be processed into ethanol for biofuels. Many…

Poplar esterified cell wall transformations and metabolic integration (PECTIN) study

Lead Institution

Lawrence Berkeley National Laboratory

Principal Investigator

Kolby Jardine

Project type

Exploratory Research

Polysaccharides are major components of plant cell walls that can be converted into fuels by microbial fermentation, making plant biomass an important bioenergy resource. However, a substantial…

Surface analysis of metal carbides

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Yongsoon Shin

Project type

Exploratory Research

Oxygen content of the metal carbides such as silicon carbide, titanium carbide, ngsten carbide will be analyzed using XPS.

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