Projects

Membrane proteins of placental parasites

Lead Institution

Seattle Biomedical Research Institute

Principal Investigator

Michal Fried

Project type

Exploratory Research

Plasmodium falciparum parasites differ from other malaria parasite species that infect human by its ability to sequester in deep vascular beds and adhere to molecules expressed on the endothelium. It…

Biomarkers of malaria infection

Lead Institution

Seattle Biomedical Research Institute

Principal Investigator

Michal Fried

Project type

Large-Scale EMSL Research

This application is for the continuation and expansion of proposal 8211 "Membrane proteins of placental parasites". P. falciparum causes severe syndromes by adhering to endothelium and…

Computational chemical and materials science to study nanoscale surface reactivity and radiation resistance of metal oxides

Lead Institution

University of Minnesota

Principal Investigator

Joern Siepmann

Project type

Exploratory Research

This particular research in the Molecular Interactions and Transformations group is aimed at achieving a fundamental molecular level understanding of the generation, transport and fate of excited…

Image polystyrene microparticles

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Ozanich

Project type

Exploratory Research

obtain SEM images of 1-10 micron polystyrene microspheres to examine surface features

Influence of Flow on Abiotic and Biotic Reactivity of CL--20 (hexaanitrohexaazaiso-wurtzitane) (PNNL Scope # 42095)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

James Szecsody

Project type

Exploratory Research

Mechanistic studies of surface bound natural FeII , or surface bound biogenically or chemically reduced Fe on the degradation kinetics of CL-20 (hexaanitrohexaazaiso-wurtzitane) are being conducted…

Direct Numerical Simulations of Turbulent Combustion- Temperature Inhomogeneity Effects on the Autoignition of H2/Air Mixtures in the Sponteneous Ignition Regime

Lead Institution

Sandia National Laboratory

Principal Investigator

Jacqueline Chen

Project type

Exploratory Research

Recent DNS of lean hydrogen-air ignition at high pressure at constant volume with temperature inhomogeneities showed the dual significance of scalar dissipation- first, limiting the minimum…

CONTROLLED DEFECT GENERATION IN POROUS SILICON

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Donald Baer

Project type

Exploratory Research

Nanoporous silicon surface has been subject to considerable study because of its photoemmsion properties and possible opto-chemical, gas and bio sensing applications. The ability to get controlled…

ATM, ISO and other standard and metrology measurements for surface analysis

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Donald Baer

Project type

Exploratory Research

This activity involves extended that state of the art in surface analysis by expanding the understanding of equipment capability, testing new approaches to instrument calibration and operation, and…

Test Measurements and Approaches for Enhancing Information Available from Surface Analysis of Oxides, nanoparticles and organic materials analysis

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Donald Baer

Project type

Large-Scale EMSL Research

This activity involves extending the state of the art in surface analysis by expanding the understanding of equipment capability, testing new approaches to instrument calibration, operation and data…

Ion Channeling Studies of Epitaxial Oxide Films and Gas-Solid interfaces.

Lead Institution

Wayne State University

Principal Investigator

Karur Padmanabhan

Project type

Exploratory Research

The proposal addresses two important research areas using the on RBS, ion channeling and nuclear reaction analysis. EMSL ion accelerator facility will be used for both projects. The first involves…

Ion Channeling Studies of Epitaxial Oxide Films and Gas-Solid interfaces.

Lead Institution

Wayne State University

Principal Investigator

Karur Padmanabhan

Project type

Large-Scale EMSL Research

The proposal addresses two important research areas using the on RBS, ion channeling and nuclear reaction analysis. EMSL ion accelerator facility will be used for both projects. The first involves…

Quantum and classical simulations of clusters, self-assembly, nano-scale manipulations, nanotribology, and biological processes.

Lead Institution

Georgia Institute of Technology

Principal Investigator

Uzi Landman

Project type

Exploratory Research

In this project, new to MSCF at PNNL but already granted time there by DOE, We continue the ongoing development, implementation and use of quantum and classical modeling and simulation methodologies…

Conductivity of bacterial nanowires

Lead Institution

J. Craig Venter Institute

Principal Investigator

Yuri Gorby

Project type

Exploratory Research

Scanning tunneling microscopy will be used to image and characterize bacterial appendages produced by iron reducing bacteria that are believed to be involved with the extracellular reduction of iron…

Image Acquisition and Analysis of Fluorescent Biological Samples

Lead Institution

Washington State University

Principal Investigator

Benjamin Arthurs

Project type

Exploratory Research

We will use fluorescence microscope with a laser scanning and camera imaging acquisition to examine both bacteria and mouse cells.

A combined approach for protein structure prediction

Lead Institution

Lawrence Berkeley National Laboratory

Principal Investigator

Silvia Crivelli

Project type

Exploratory Research

The protein structure prediction is one of the grand challenges in modern science. The problem consists of determining the tertiary structure of a protein given its primary sequence of amino acids…

A combined approach for protein structure prediction and protein-protein docking

Lead Institution

Lawrence Berkeley National Laboratory

Principal Investigator

Silvia Crivelli

Project type

Exploratory Research

Mapping the network of protein interactions in the cells of living organisms is an intriguing puzzle that we are just beginning to understand with the knowledge of completed genomes. Predicting the…

Soft Lithography for Optics

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Glen Dunham

Project type

Exploratory Research

The method of soft lithography will be applied to fabrication of absorptive optical filters.

Nanomaterial toxicology

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Donald Baer

Project type

Exploratory Research

The immense excitement created by the developing ability to manipulate many physical and chemical properties of nanoscale objects also raises question of nanomaterial toxicity. In contrast to well…

Photoelectron Spectroscopic Studies of Complex Anion Solvation in the Gas Phase (Kay's BES-Surface Kinetics, PNNL Scope #16248)

Lead Institution

Brown University

Principal Investigator

Lai-Sheng Wang

Project type

Exploratory Research

Hydration is important for the function of biomolecules. Gas phase studies of hydrated clusters provide a valuable means to obtain molecular level information about ionic solvation. We produce…

Phosphorous poisoning of automotive catalysts

Lead Institution

Oak Ridge National Laboratory

Principal Investigator

Bruce Bunting

Project type

Exploratory Research

Phosphorous is contained in lube oil in the form of zinc dialkyldithiophosphate. Although progress has been made in reducing the total phosphorous in lube oil, it appears that it can not be…