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David Wunschel

Institution
Pacific Northwest National Laboratory
ORCID
ORCID logo 0000-0001-5693-8514

Projects

Forensic Proteomics of Viruses

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Wunschel
The previous proteomic analysis of vaccinia virus (VV) and Monkeypox viruses has indicated that a significant amount of host cellular protein associates itself with virus preparations. Some of these…

Understanding Ferrichrome Structural Interaction with Uranium Compounds

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Wunschel
Project type
Special Science
Siderophores are generally low molecular weight iron chelating compounds that are essential for plant and microbial iron acquisition. These compounds are released into the environment to mobilize…

Identification of Metabolite Toxins

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Wunschel
This project will collect data on ion-mobility, accurate mass and compound fragmentation data using an ESI-IMS-MS/MS system for a number of metabolite toxins and structurally similar compounds. This…

Identification of Algal and Cyanobacterial Toxins

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Wunschel
This proposal is for data collection on the LC-ESI-IMS-MS/MS systems in EMSL for identification of algal and cyanobacterial toxins in biological samples. This work will builds off of previous EMSL…

Nanopore Platforms for Protein Analysis

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jayde Aufrecht
Nanopore-based protein sensing has the potential to revolutionize the field of proteomics by providing single-molecule protein sequencing at amino acid level resolution. However, even if nanopore…

Peptide biomarker Analysis

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Wunschel
This proposal is for use of ESI-MS (LTQ orbitrap)for analysis of native peptide markers. Sets of peptide masses from the LC-MS runs will be acquired and initially used as raw data for comparison…

Peptide biomarker Analysis

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Wunschel
This proposal is for use of ESI-MS (LTQ orbitrap)for analysis of native peptide markers. Sets of peptide masses from the LC-MS runs will be acquired and initially used as raw data for comparison…

Investigations of Microbial Spore Lysis using Near-IR Laser Irradiation.

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Wunschel
Project type
Exploratory Research
The rapid detection of a microorganism in the environment requires the detection of a specific biochemical marker or markers. In characterizing a particular microbial isolate, it is desirable to…

Growth Media Component Peptide and Carbohydrate Analysis

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Karen Wahl
The objective of this project is to utilize resource instrumentation to develop and characterize a method to detect residual peptides from growth media in the final bacterial samples for bioforensics…

Combined Castor Marker and Isotope Profile for Ricin Forensics

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Helen Kreuzer
There is a need for a number of independent analytical techniques to associate different ricin samples with each other, correlate to source materials, or demonstrate processing steps have occurred…