Solid State NMR Characterization of Hydrogenase
EMSL Project ID
36397
Abstract
Hydrogenase is a naturally occurring enzyme that efficiently converts H2->2H+ + 2e- and is reversible. Producing synthetic catalysts with these properties is highly desirable, but current analogs cannot match the low overpotentials and the fastest rates of the enzyme. Understanding how the enzyme works is an essential first step in the intelligent development of synthetic catalysts. A thorough understanding of the structure will likely reveal key details in functional properties of the enzyme. This work proposes to investigate the full structure of hydrogenase using solid state NMR, including the unique 900 MHz capability housed in the EMSL facility.
Project Details
Project type
Exploratory Research
Start Date
2009-10-14
End Date
2010-10-17
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members
Related Publications
Chua YS, W Li, WJ Shaw, G Wu, T Autrey, Z Xiong, MW Wong, and P Chen. 2012. "Mechanistic Investigation on the Formation and Dehydrogenation of Calcium Amidoborane Ammoniate." ChemSusChem 5(5):927-931. doi:10.1002/cssc.201100523