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Undiagnosed Diseases Network Metabolomics Core


EMSL Project ID
50589

Abstract

A state of the art metabolomics core will be a vital part of the Undiagnosed Diseases Network (UDN). However, in order for the UDN to realize it’s the full potential it is essential that the metabolomics core doesn’t simply function as a high tech referral lab. We propose the formation of a partnership that will combine the state of the art analytical capabilities of the Pacific Northwest National Laboratory (PNNL), with clinical, genetic, and bioinformatics expertise from Oregon Health & Science University (OHSU), to create a metabolomics core that functions as a fully integrated component of the network. The integration of this combined expertise will facilitate the linkage of novel metabolites or patterns of metabolites identified by the metabolomics core to the underlying metabolic and genetic derangements, as well as clinical signs and symptoms, and to translate this knowledge into specific clues regarding the genetic etiology of the patient’s disorder. The following specific aims describe the approach we will use to create the UDN Metabolomics Core (UDNMC).

Project Details

Start Date
2018-10-01
End Date
2019-08-02
Status
Closed

Team

Principal Investigator

Thomas Metz
Institution
Pacific Northwest National Laboratory

Team Members

Sarah Williams
Institution
Environmental Molecular Sciences Laboratory

Jennifer Kyle
Institution
Pacific Northwest National Laboratory

Young-Mo Kim
Institution
Pacific Northwest National Laboratory

Jason McDermott
Institution
Pacific Northwest National Laboratory

Bobbie-Jo Webb-Robertson
Institution
Pacific Northwest National Laboratory