Projects

Solid-State NMR Structural Studies of HIV-1 CA Protein Assembly

Lead Institution

University of Delaware

Principal Investigator

Tatyana Polenova

Project type

Large-Scale EMSL Research

This is an application in response to the proposal call "Science Theme: Biological Interactions and Dynamics". We request standard, general non-proprietary access to the 900 MHz solid-state…

Mechanisms of nanocrystalline uraninite oxidation by iron minerals under of sulfate-reducing bacteria

Lead Institution

South Dakota School of Mines and Technology

Principal Investigator

Rajesh Sani

Project type

Large-Scale EMSL Research

Uranium (U) is the most common radionuclide in soils, sediments, and groundwater at many sites including U.S. DOE sites and is therefore of particular environmental concern. Subsurface bacteria such…

Comprehensive Analysis Of Post-Translational Modifications (PTMs) In Proteins Involved In Histone Pre-mRNA Processing By High Performance nanoLC-MS

Lead Institution

University of North Carolina

Principal Investigator

Roopa Thapar

Project type

Large-Scale EMSL Research

All eukaryotic mRNAs undergo a series of posttranscriptional processing events that lead to the generation of a mature mRNA transcript which is then translated. These pre-mRNA processing steps…

Structural basis of the lysis clock in bacteriophages: the holin-antiholin interaction of phage lambda

Lead Institution

Texas A&M University

Principal Investigator

Christian Hilty

Project type

Large-Scale EMSL Research

Bacteria are the most abundant organisms in the biosphere, and, after cell division, the second most common fate of bacterial cells is lysis by bacteriophage. For most bacteriophages, the duration…

Proteomic Analysis of Extracellular Appendages Displayed in Desulfovibrio vulgaris

Lead Institution

Oak Ridge National Laboratory

Principal Investigator

Dwayne Elias

Project type

Large-Scale EMSL Research

Sulfate-reducing bacteria makeup a substantial portion of subsurface microbial communities at DOE contaminated sites in particular. They are capable of reducing and immobilizing, soluble U(VI) by…

Phosphoproteomic profiling of breast cancer cell lines

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Arzu Umar

Project type

Large-Scale EMSL Research

Breast cancer is a very heterogeneous disease, consisting of different molecular subtypes. Effective, targeted treatment is available for estrogen receptor (ER) and human epidermal growth factor…

Abiotic reduction of U(VI) by sorbed Fe(II) and the implications for field-scale bioremediation at the Rifle IFC project site

Lead Institution

US Geological Survey, Menlo Park

Principal Investigator

Kate Campbell

Project type

Large-Scale EMSL Research

Bioremediation of uranium-contaminated sites has recently been explored as a potentially effective groundwater treatment option. The injection of an organic carbon substrate such as acetate…

Simultaneous Optical & Chemical Measurements of Aerosols as a Function of Relative Humidity: Bridging Laboratory and Field Measurements to Models

Lead Institution

Los Alamos National Laboratory

Principal Investigator

Manvendra Dubey

Project type

Large-Scale EMSL Research

Interactions of anthropogenic aerosols with solar radiation and clouds and are the largest source of uncertainty in climate change science. The key science gap is a lack of process-level knowledge…

The Influence of different Fe(III) Phases and the Effect of Sulfate Reduction on the Simultaneous Bioreduction of Iron and Uranium

Lead Institution

Princeton University

Principal Investigator

Peter Jaffe

Project type

Large-Scale EMSL Research

Biostimulation of Fe(III) and/or sulfate reducing microorganisms by addition of acetate can effectively reduce U(VI). However, U(VI) removal from groundwater was hindered in field trials at the…

Probing the Reactivity of Organic Particles Using Ion Soft-Landing

Lead Institution

University of California, Irvine

Principal Investigator

Sergey Nizkorodov

Project type

Large-Scale EMSL Research

Formation and atmospheric processing of particulate matter is one of the focus areas emphasized by EMSL. Organic coatings on atmospheric aerosols determine the surface chemistry that particles…

Scanning and Transmission Electron Microscopy of Grape Berry Shrivel

Lead Institution

Washington State University Tri-Cities

Principal Investigator

Bhaskar Bondada

Project type

Large-Scale EMSL Research

The state of Washington is the second largest producer of premium wine in the nation and is ranked among the worlds top wine regions. Washington wines are found nationally in all 50 states and…

Proteomic-based analysis of components involved in Human cytomegalovirus US28-induced cellular migration

Lead Institution

Oregon Health & Science University

Principal Investigator

Daniel Streblow

Project type

Large-Scale EMSL Research

Our goal is to identify the molecular mechanisms involved in Pyk2 signaling in response to activation by the Human cytomegalovirus (HCMV)-encoded chemokine receptor US28. We propose to utilize…

Fundamental Studies of Nitrogen Oxide Surface Chemistry: A Model System Approach Combining Experiments and Theory

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Janos Szanyi

Project type

Large-Scale EMSL Research

This program is aimed at the development of a fundamental understanding of catalytic nitrogen oxide (NOx) chemistry on base metal oxide surfaces. Special emphasis is on identifying new and unique…

Modeling charge transport and interfacial chemistry at the nanoscale

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Ram Devanathan

Project type

Large-Scale EMSL Research

Understanding charge transfer, charge transport and molecular transport in nanomaterials and interfaces in solids (such as grain boundaries, interfaces in multilayer materials, and hydrophilic…

Investigations into the Protein-Mineral Interface

Lead Institution

The Ohio State University

Principal Investigator

Steven Lower

Project type

Large-Scale EMSL Research

We propose to use a combination of experimental and computational techniques to investigate the protein-mineral interface. Namely, we will use atomic force microscopy to measure nano-scale forces…

NMR and Computational Studies of Chemical Transformations at Complex Interfaces for Catalytic Applications

Lead Institution

University of Alabama

Principal Investigator

David Dixon

Project type

Large-Scale EMSL Research

Catalysis science is at the core of many of the DOE's programs including its core energy mission. Catalysts, both homogeneous and heterogeneous, facilitate the control of chemical reactions by…

Characterization of Aerosol Organics by LC-MSn

Lead Institution

Desert Research Institute

Principal Investigator

Barbara Zielinska

Project type

Large-Scale EMSL Research

In summer, 2009, a comprehensive field study is planned to characterize the effect of organics on the water activity of atmospheric particles under sub- and supersaturated conditions at the Desert…

Preparation of Stoichiometric TiO2(110)-(1x1) Surface.

Lead Institution

Fritz-Haber-Institut der Max-Planck-Gesellschaft

Principal Investigator

Hans-joachim Freund

Project type

Large-Scale EMSL Research

Driving force for investigations of single-crystalline TiO2 surfaces is the wide range of its applications from photocatalysis to degradation of organic pollutants. Rutile TiO2 (110) surface is a…

A model system to obtain structural information from the bacterial-mineral interface by neutron reflectometry

Lead Institution

Oak Ridge National Laboratory

Principal Investigator

Alexander Johs

Project type

Large-Scale EMSL Research

Electron transfer to insoluble electron acceptors by dissimilatory metal-reducing bacteria is facilitated by a pool of c-type cytochromes associated with the bacterial outer membrane. Recent studies…

Uncovering proteogenomic patterns on an evolutionary gradient of termite gut Verrucomicrobia isolates.

Lead Institution

University of California, Davis

Principal Investigator

Jorge Rodrigues

Project type

Large-Scale EMSL Research

Cellulositic biomass for biofuel conversion is inexpensive and abundant, but efficient biotransformation is still a challenge. Wood-feeding termites harbor a microbial community dedicated to degrade…