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Louis Pete Silks

Institution
Los Alamos National Laboratory

Projects

DNA and Protein Molecules

Lead Institution
Los Alamos National Laboratory
Principal Investigator
Louis Pete Silks
Project type
Capability Research
DNA and protein molecules can be aligned in high magnetic fields producing spectroscopic features in nuclear magnetic resonance (NMR) spectra that can be used to significantly improve the quality of…

NMR Structure Characterization of isotopically labeled DNA Oligonucleotides

Lead Institution
Los Alamos National Laboratory
Principal Investigator
Louis Pete Silks
Project type
Capability Research
DNA structure determination by nuclear magnetic resonance (NMR) spectroscopy is an under-restrained problem in general. Isotopic-labeling considerably increases the number and type of NMR…

Ultra-High Field NMR Studies of Stable Isotope Applications

Lead Institution
Los Alamos National Laboratory
Principal Investigator
Louis Pete Silks
Project type
Capability Research
DNA structure determination by nuclear magnetic resonance (NMR) spectroscopy is an under-restrained problem in general. Isotopic-labeling considerably increases the number and type of NMR…

Ultra-High Field NMR Studies of Stable Isotope Applications

Lead Institution
Los Alamos National Laboratory
Principal Investigator
Louis Pete Silks
Project type
Capability Research
The primary goal of this project is to develop and implement new approaches for using isotopic labels in NMR-based DNA structure determination that will allow highly accurate NMR-based DNA structure…

Ultra-High Field NMR Studies of Stable Isotope Applications

Lead Institution
Los Alamos National Laboratory
Principal Investigator
Louis Pete Silks
Project type
Capability Research
We have synthesized several 15N,13C-labeled oligomers (labeled residues in bold) 5'-GGGAACAACTAG-3':3'-CCCTTGTTGATC-5' and 5'-GGGATCCACTAG-3':3'-CCCTAGGTGATC-5&#039…