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Robert Wind

Institution
Pacific Northwest National Laboratory

Projects

Combined NMR/Optical Microscopy for Oral Biofilm Physiology Studies

Lead Institution
Washington State University
Principal Investigator
Paul Majors
Project type
Capability Research
Dental caries disease is one of the most prevalent and costly bacterial infections in humans. Caries and associated tooth decay are strongly correlated with a pH decrease induced by oral biofilms …

In Vivo and ex vivo High Resolution slow-MAS MR Spectroscopy in Mice

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Robert Wind
Project type
Capability Research
The overall goal of this project is to develop a methodology to increase the resolution of magnetic resonance (MR) metabolite spectra in excised tissues and live mice. Although MR spectroscopy is…

Characterization of in vivo 1H-NMR biomarkers for pulmonary phospholipidosis

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Robert Wind
Project type
Capability Research
Pulmonary phospholipidosis is a phospholipid storage disorder that can occur in humans and is inducible in laboratory animals upon inhalation of different airborne agents, including –silica dust,…

Characterization of In-Vivo 1H-NMR Biomarkers for Pulmonary Phospholipidosis

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jian-zhi Hu
Project type
Capability Research
The primary goal of this project is to test the potential utility of slow MAS 1H-NMR methods for directly monitoring pulmonary phospholipid accumulation in live animals and in real-time. It is…

Aquaporins

Lead Institution
Massachusetts General Hospital East and Harvard University School of Medicine
Principal Investigator
Dennis Brown
Project type
Capability Research
The objective of this multidisciplinary project is to investigate the application of NMR spectroscopy using the newly developed combined confocal/NMR microscope to aquaporin biology. The project is…

Slow-MAS NMR methodology developments

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Robert Wind
Project type
Capability Research
At PNNL methodologies are under development to improve the resolution of 1H NMR metabolite spectra in intact biological objects (cells, organs, tissues, and even live animals) in a non- or minimally…

In Vivo High Resolution slow-MAS MR Spectroscopy in Mice

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Robert Wind
Project type
Capability Research
The overall goal of this proposal, that is supported by NIH/NIB, is to develop and evaluate a methodology to increase the resolution of magnetic resonance (MR) metabolite spectra in live mice. …