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Investigating the interactions between linker and drug molecules and nanocrystalline surface along with cytotoxicity measurements

EMSL Project ID


Identifying and synthesizing a target specific and controlled release nanoparticle based drug delivery system (DDS) provides a great potential to overcome the barriers facing existing cancer therapy strategy. Nanocrystalline cellulose (NCC) represents a new class of bio-nanomaterial with unique characteristics that are promising for targeted DDS applications. Recently published works demonstrated the potential of NCC for drug delivery application by showing NCC has suitable surfaces for drug binding and that NCC DDS can bind to cancer cells. However, several pieces of key information are lacking, including the cytotoxicity, stability, drug release control and target specificity. In the proposed work we will only address the cytotoxicity and stability. We will design systematic studies to understand the influence of size, charge and behavior of pure and functionalized NCC in in-vitro physiological environments and to understand the interactions between drug and linker molecules with NCC surfaces.

Project Details

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Principal Investigator

Theva Thevuthasan
Environmental Molecular Sciences Laboratory

Team Members

Xiaohui Ju
Washington State University Tri-Cities

Hongfei Wang
Fudan University

Xiao Zhang
Washington State University Tri-Cities

Elvie Brown
Washington State University Tri-Cities

Related Publications

Ju X, ME Bowden, MH Engelhard, and X Zhang. 2014. "Investigating Commercial Cellulase Performances Toward Specific Biomass Recalcitrance Factors Using Reference Substrates." Applied Microbiology and Biotechnology. doi:10.1007/s00253-013-5450-4
Ma R, M Guo, and X Zhang. 2014. "Selective Conversion of Biorefinery Lignin into Dicarboxylic Acids." ChemSusChem 7(2):412-415. doi:10.1002/cssc.201300964