Understanding the effect of etching medium in tuning the surface polarity of silica nanoparticles for tuning the loading and release of anticancer drugs
EMSL Project ID
49752
Abstract
Silica nanoparticles have traditionally been used in drug delivery owing to their easy synthesis, nearly inert behaviour and ability to tune its surfaces for attaching targeting moieties. Recently etching silica nanoparticles with selected etching agents have also been explored as means of increasing the drug adsorption capacity as etching increases the active surface area available for adsorption of drugs. It is generally assumed that increase in surface area results in increase in drug adsorption as well as its release in the suitable medium. Our recent experimentation with etching silica nanoparticles surfaces for increasing the adsorption of docetaxel, a hydrophobic anticancer drug, suggest that the etching medium can significantly influence the drug uptake and release. While etching increases the surface area of the silica nanoparticles it also chemically modifies its surfaces resulting higher uptake of the hydrophobic drug as compared to unetched silica nanoparticles. However the cumulative drug release from the etched silica nanoparticles was lower than the drug release from unetched silica nanoparticles suggesting that the drug was adsorbed more strongly on the etched surface than the unetched surfaces. Based on this observation it is hypothesized that etching silica nanoparticles modifies the polarity of the surfaces resulting in strong interaction of the hydrophobic drug with silica nanoparticles. Based on this hypothesis the aim of the present study is to evaluate the surface chemistry of silica nanoparticles etched in different mediums and correlate with the experimental observations of drug uptake and release studies. This study would result in modifying the design of silica based drug delivery vehicles for fighting against diseases such as cancers.Project Details
Start Date
2017-03-20
End Date
2019-09-30
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members
Related Publications
Chang H., X. Lu, J.F. Bonnett, N.L. Canfield, K. Han, M.H. Engelhard, and K. Jung, et al. 2018. "Decorating ß"-alumina solid-state electrolyte with submicron Pb spherical particles for improving Na wettability at lower temperatues." Journal of Materials Chemistry A 6, no. 40:19703-19711. PNNL-SA-135511. doi:10.1039/C8TA06745G
Chatterjee S, B Singh, A Diwan, Z Lee, MH Engelhard, JH Terry, D Tolley, NB Gallagher, and MR Linford. 2018. "A Perspective on Two Chemometrics Tools: PCA and MCR, and Introduction of a New One: Pattern Recognition Entropy (PRE), as Applied to XPS and ToF-SIMS Depth Profiles of Organic and Inorganic Materials." Applied Surface Science 433:994-1017. doi:10.1016/j.apsusc.2017.09.210
Guo Z., M. Shams, C. Zhu, Q. Shi, Y. Tian, M.H. Engelhard, and D. Du, et al. 2019. "Electrically Switched Ion Exchange Based on Carbon-polypyrrole Composite Smart Materials for the Removal of Re04- from Aqueous Solutions." Environmental Science & Technology 53, no. 5:2612-2617. PNNL-SA-131524. doi:10.1021/acs.est.8b04789
Song J., D. Xiao, H. Jia, G. Zhu, M.H. Engelhard, B. Xiao, and S. Feng, et al. 2019. "A Comparative Study of Pomegranate Sb@C Yolk-Shell Microspheres as Li and Na-Ion Battery Anodes." Nanoscale 11, no. 1:348-355. PNNL-SA-139714. doi:10.1039/c8nr08461k