Development of a nano-desorption atmospheric pressure photoionization (nano-DAPPI) advanced mass spectrometry platform
EMSL Project ID
51157
Abstract
Natural organic matter from atmospheric aerosol and soil consist of complex molecules with range of polar and non-polar compounds. Previously EMSL developed a unique platform, nano-desorption electrospray ionization combined with high-resolution mass spectrometry (nano-DESI-HRMS) for detailed chemical characterization and studies of chemical aging of organic aerosol samples collected on substrates. Nano-DESI-HRMS provides rapid characterization (no sample preparation and extraction, minimal residence time of analyte in the solvent, and small amount of sample) of organic aerosol and other natural organic matter. While ESI is more efficient at detection of polar compounds, APPI is more efficient at detection of aromatic and nonpolar. Positive and negative ESI and APPI technique can provide a more complete picture of organic aerosol. However, the current APPI source requires extracted samples, and it is thus not possible to analyze the sample directly from the substrate. This makes it challenging to compare nano-DESI and APPI. We propose to develop a nano-desorption atmospheric pressure photoionization (nano-DAPPI) advanced mass spectrometry platform for characterization of natural organic matter such as aerosol and soil. The proposed platform will be able to directly compare two complimentary techniques and may have future applications for spatially resolved analysis (imaging). This will have broad implications for advanced natural organic matter research.
Project Details
Start Date
2019-10-01
End Date
2021-09-30
Status
Closed
Released Data Link
Team
Principal Investigator
Team Members