Integrative Multi-PTM Profiling by an Automated Shotgun Proteomics Coupled with Top-down Proteomics
EMSL Project ID
60673
Abstract
To use PTM data to understand cell signaling and profile molecular phenotypes, PNNL has made substantial strides in advancing phosphoproteome and thiol redox proteome profiling. However, the current workflows are extremely tedious, labor-intensive, and low throughput. In addition, it is still challenging to characterize multiple PTMs to elucidate crosstalk or coordinated regulations simultaneously. This proposal will tackle these challenges by developing an automated and scalable capability for high-throughput integrative analysis of multiple PTMs.
Project Details
Start Date
2023-01-27
End Date
2023-09-30
Status
Closed
Released Data Link
Team
Principal Investigator
Co-Investigator(s)
Team Members