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Marina Gritsenko

Institution
Pacific Northwest National Laboratory

Projects

Genome-Enabled Characterization of Orphan Receptor-Like Kinases in Plants

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Ljiljana Pasa-Tolic
This research will characterize the functions and clients (i.e., substrates) of receptor-like kinases (RLKs) of Arabidopsis, rice, and soybean. Objective 1 will reveal RLK functions by combing…

CPTAC Proteome Characterization Center

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Tao Liu
The overall objective of the PNNL Proteome Characterization Center (PCC) is to comprehensively characterize human tumor samples provided by the National Cancer Institute (NCI), and to integrate the…

PTRC Proteogenomic Translational Research Center

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Paul Piehowski
Due to the complexity of signaling and sequence modifications in cancer, predictions of pathway regulation and dependence based upon genomic data alone is challenging. This research proposal will…

Multi-platform 'Omics Analysis to Determine TB Vaccine Correlates

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jennifer Kyle
In recent years, mass spectrometry-based integrated multi-omics analyses have allowed for powerful interrogations of patient samples, and the identification of correlates of risk for tuberculosis…

Neurospora Quantitative Proteomics Study

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Feng Yang
We propose to obtain quantitative proteomics and phosphoproteomics data for Neurospora grown on three different media using the high through-put and sensitive LC-MC/MS capabilities available in EMSL…

Massively Parallel Molecular Profiling of Breast Cancer

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
Molecular profiling of breast cancer into subcategories based on functional ER expression and amplification of HER2 has significantly enhanced our understanding of the disease, and has pointed the…

Proteomic Studies of type 2 diabetes using knockout mouse models

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Weijun Qian
This is an NIH-funded R01 project on diabetes research. A central goal of diabetes research (type 1 and type 2) is to generate large numbers of functional islets or beta-cells for replacement…

Massively Parallel Molecular Profiling of Breast Cancer

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
Molecular profiling of breast cancer into subcategories based on functional ER expression and amplification of HER2 has significantly enhanced our understanding of the disease, and has pointed the…

CPTAC Proteome Characterization Center

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Tao Liu
The overall objective of the PNNL Proteome Characterization Center (PCC) is to integrate genomic information with proteomic technologies to comprehensively characterize the proteome and post…

Serum biomarkers for predicting type 1 diabetes

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Weijun Qian
Clinical type 1 diabetes (T1D) is preceded by an asymptomatic phase of the disease, which can be readily identified by serum islet autoantibodies(AAb). However, the T1D field is challenged by the…

PTRC Proteogenomic Translational Research Center

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Karin Rodland
Due to the complexity of signaling and sequence modifications in cancer, predictions of pathway regulation and dependence based upon genomic data alone is challenging. This research proposal will…

PTRC Proteogenomic Translational Research Center

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Paul Piehowski
Due to the complexity of signaling and sequence modifications in cancer, predictions of pathway regulation and dependence based upon genomic data alone is challenging. This research proposal will…

CPTAC Proteome Characterization Center

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Tao Liu
The overall objective of the PNNL Proteome Characterization Center (PCC) is to integrate genomic information with proteomic technologies to comprehensively characterize the proteome and post…