Marina Gritsenko | Environmental Molecular Sciences Laboratory

Genome-Enabled Characterization of Orphan Receptor-Like Kinases in Plants

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Ljiljana Pasa-Tolic

This research will characterize the functions and clients (i.e., substrates) of receptor-like kinases (RLKs) of Arabidopsis, rice, and soybean. Objective 1 will reveal RLK functions by combing…

Integrative Multi-PTM Profiling by an Automated Shotgun Proteomics Coupled with Top-down Proteomics

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tong Zhang

Project type

Contracted Time

To use PTM data to understand cell signaling and profile molecular phenotypes, PNNL has made substantial strides in advancing phosphoproteome and thiol redox proteome profiling. However, the current…

Integrative Multi-PTM Profiling by an Automated Shotgun Proteomics Coupled with Top-down Proteomics

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tong Zhang

To use PTM data to understand cell signaling and profile molecular phenotypes, PNNL has made substantial strides in advancing phosphoproteome and thiol redox proteome profiling. However, the current…

CPTAC Proteome Characterization Center

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The overall objective of the PNNL Proteome Characterization Center (PCC) is to comprehensively characterize human tumor samples provided by the National Cancer Institute (NCI), and to integrate the…

Molecular Mechanisms Underlying Cellular Adaptive Response to Low Dose Radiation

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Colette Sacksteder

The goal of this research is to identify the molecular mechanisms by which cells adapt to low dose radiation exposure. We hypothesize that calmodulin (CaM) and associated signaling complexes are…

Serum biomarkers for predicting type 1 diabetes

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

Clinical type 1 diabetes (T1D) is preceded by an asymptomatic phase of the disease, which can be readily identified by serum islet autoantibodies(AAb). However, the T1D field is challenged by the…

Title: Advanced Proteomics and Metabolomics Studies of Type 2 Diabetes and Pre-Diabetes

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Metz

Abstract: In this five year (R21/R33) project we will apply advanced proteomic and metabolomic nanoflow liquid chromatography-Fourier transform ion cyclotron resonance (FTICR) mass spectrometry…

PTRC Proteogenomic Translational Research Center

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Karin Rodland

Due to the complexity of signaling and sequence modifications in cancer, predictions of pathway regulation and dependence based upon genomic data alone is challenging. This research proposal will…

High Throughput Proteomic & Metabolomic Early Biomarkers (PNNL Scope #47174, RD Smith's EIF project)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

Proteomic and metabolomic applications of high throughput, quantitative measurements using the accurate mass and time (AMT) tag approach for discovering early biomarkers in blood plasma and nipple…

PTRC Proteogenomic Translational Research Center

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Paul Piehowski

Due to the complexity of signaling and sequence modifications in cancer, predictions of pathway regulation and dependence based upon genomic data alone is challenging. This research proposal will…

High-Throughput Proteomics: Applications and Development (PNNL Scope #40601 and #43488)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Gordon Anderson

This project involves the application and development of high-throughput proteomics and quantitative measurement capabilities within biological systems. More so, application measurements will be…

CPTAC Proteome Characterization Center

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The overall objective of the PNNL Proteome Characterization Center (PCC) is to integrate genomic information with proteomic technologies to comprehensively characterize the proteome and post…

Early Breast Cancer Biomarkers Verification (PNNL Scope #47174, RD Smith's EIF project)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

Our overall objective for studies performed in Years 4 to 6 is to contribute to the assembly of a highly confident protein panel for the early detection of breast cancer by applying the PNNL…

PTRC Proteogenomic Translational Research Center

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Paul Piehowski

Due to the complexity of signaling and sequence modifications in cancer, predictions of pathway regulation and dependence based upon genomic data alone is challenging. This research proposal will…

Center for Application of Advanced Clinical Proteomic Technologies for Cancer (NCI U24; 59963)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The overall objective of the PNNL Clinical Proteome Characterization Center (PCPCC) is to facilitate cancer biomarker development by linking the cancer genotype to the cancer phenotype using detailed…

Multi-platform 'Omics Analysis to Determine TB Vaccine Correlates

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jennifer Kyle

In recent years, mass spectrometry-based integrated multi-omics analyses have allowed for powerful interrogations of patient samples, and the identification of correlates of risk for tuberculosis…

Neurospora Quantitative Proteomics Study

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Feng Yang

We propose to obtain quantitative proteomics and phosphoproteomics data for Neurospora grown on three different media using the high through-put and sensitive LC-MC/MS capabilities available in EMSL…

Pan-Omics Technology Development, Implementation, and Application to GSP Systems Biology Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The BER Genome Science Program aims to understand complex biological and environmental systems across spatial and temporal scales to develop predictive knowledge relevant to DOE mission challenges…

Massively Parallel Molecular Profiling of Breast Cancer

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Smith

Molecular profiling of breast cancer into subcategories based on functional ER expression and amplification of HER2 has significantly enhanced our understanding of the disease, and has pointed the…

Proteomic Studies of type 2 diabetes using knockout mouse models

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

This is an NIH-funded R01 project on diabetes research. A central goal of diabetes research (type 1 and type 2) is to generate large numbers of functional islets or beta-cells for replacement…

Center for Application of Advanced Clinical Proteomic Technologies for Cancer (NCI U24; 59963)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Smith

The overall objective of the PNNL Clinical Proteome Characterization Center (PCPCC) is to facilitate cancer biomarker development by linking the cancer genotype to the cancer phenotype using detailed…

Massively Parallel Molecular Profiling of Breast Cancer

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Smith

Molecular profiling of breast cancer into subcategories based on functional ER expression and amplification of HER2 has significantly enhanced our understanding of the disease, and has pointed the…

Pan-Omics Technology Development, Implementation, and Application to GSP Systems Biology Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The BER Genome Science Program aims to understand complex biological and environmental systems across spatial and temporal scales to develop predictive knowledge relevant to DOE mission challenges…

Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

In type 1 diabetes (T1D) research there remains a critical need for having a systems level understanding of the early stage molecular mechanisms that trigger the specific destruction of pancreatic β…

Pan-Omics Technology Development, Implementation, and Application to GSP Systems Biology Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The BER Genome Science Program aims to understand complex biological and environmental systems across spatial and temporal scales to develop predictive knowledge relevant to DOE mission challenges…

CPTAC Proteome Characterization Center

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The overall objective of the PNNL Proteome Characterization Center (PCC) is to integrate genomic information with proteomic technologies to comprehensively characterize the proteome and post…

Projects