Projects

As a scientific user facility, the Environmental Molecular Sciences Laboratory (EMSL) provides expertise, instrumentation, and resources to 250 projects each year.

EMSL projects displayed on the EMSL web site project page reflect project abstracts and information migrated to this page before April 30, 2024. To review current and past EMSL user projects, visit EMSL Science Central.™

Accelerating the identification of novel secondary metabolites in bioenergy plant root exudates using microcrystal electron diffraction (MicroED)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Vivian Lin

Project type

Cryo-EM Only

Small molecule metabolites drive inter- and intraspecies communication and dependencies in diverse biological systems, yet a large proportion of these important chemical compounds remain…

Cryo-EM Comparison Between Cryo-FIB-EXLO and Cryo-FIB On-The-Grid Prepared Yarrowia Lipolytica Yeast

Lead Institution

EXpressLO LLC

Principal Investigator

Lucille Giannuzzi

Project type

Cryo-EM Only

Our DOE funded research (DE-SC0020511) has enabled us to develop cryo-sample handling methods that eliminate the use of a cryo focused ion beam (cryo-FIB) instrument for specimen manipulation. By…

The molecular basis for the role of apolipoprotein A-II in cholesterol and triglyceride metabolism

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

John Melchior

Project type

Cryo-EM Only

Apolipoprotein (apo)A-II is an abundant human plasma protein primarily in high-density lipoproteins (HDL) but also in very low density lipoproteins (VLDL) and chylomicrons. Despite a large literature…

Structural identification of novel, cancer associated metabolites deriving from cysteine metabolism

Lead Institution

Fred Hutchinson Cancer Research Center

Principal Investigator

Lucas Sullivan

Project type

Cryo-EM Only

Activation of the oncogenic transcription factor NRF2 in cancer cells is associated with metabolic changes that remain poorly understood. My research group has identified that NRF2 activated cancers…