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Gaetano Montelione

Institution
Rutgers University

Projects

Structural Genomics of Strongly Conserved Gene Families

Lead Institution
Rutgers University
Principal Investigator
Gaetano Montelione
Project type
Capability Research
The fundamental concept of this proposal is that structural homology between functionally related proteins is preserved over longer evolutionary timescales than sequence homology. We propose that 3D…

Protein Interactions and Interfaces

Lead Institution
Rutgers University
Principal Investigator
Gaetano Montelione
Project type
Large-Scale EMSL Research
All proteins interact with other molecules: ligands, metals, membranes, surfaces or other proteins. Such interactions are intrinsic to protein function. We propose to leverage our successful program…

Nuclear Spin Relaxation Measurements for Structural Genomics

Lead Institution
Rutgers University
Principal Investigator
Gaetano Montelione
Project type
Capability Research
We are developing an approach to extract, compile and statistically analyze information about polypeptide dynamics from 2D {N15, H1}-correlation spectra in the framework of our structural genomics…

Structural Genomics of Eukaryotic Model Organisms

Lead Institution
Rutgers University
Principal Investigator
Gaetano Montelione
Project type
Capability Research
The primary genome targets for this methodology development are eukaryotic model organisms which are subjects of extensive functional genomics research, including S. cerevisiae, C. elegans, and D…

Structural Genomics of Eukaryotic Model Organisms

Lead Institution
Rutgers University
Principal Investigator
Gaetano Montelione
Project type
Capability Research
We have recently received a NIH Center Grant in Structural Genomics establishing the Northeast Structural Genomics Consortium for evaluating the feasibility, costs, economies of scale, and value of…

Structural Genomics of Eukaryotic Model Organisms

Lead Institution
Rutgers University
Principal Investigator
Gaetano Montelione
Project type
Capability Research
The primary goal of our pilot project is to develop integrated technologies for high-throughput (htp) protein production and 3D structure determination. These will form key components of the…

Structural Genomics of Eukaryotic Model Organisms

Lead Institution
Rutgers University
Principal Investigator
Gaetano Montelione
Project type
Capability Research
The Northeast Structural Genomics Consortium is a NIH-funded pilot project aimed at evaluating the feasibility, costs, economies of scale, and value of structural proteomics. The primary goal of our…

Structural Genomics of Eukaryotic Model Organisms

Lead Institution
Rutgers University
Principal Investigator
Gaetano Montelione
Project type
Capability Research
ABSTRACT The Northeast Structural Genomics Consortium is a NIH-funded pilot project aimed at evaluating the feasibility, costs, economies of scale, and value of structural proteomics. The…

High-Throughput Structure Determination of Proteins and Protein Complexes

Lead Institution
Rutgers University
Principal Investigator
Gaetano Montelione
Project type
Large-Scale EMSL Research
The Northeast Structural Genomics Consortium (NESGC, www.nesg.org) is one of four large protein structure production centers supported by the NIH Protein Structure Initiative II (the PSI II). The…

Structural genomics of eukaryotic model organisms

Lead Institution
Rutgers University
Principal Investigator
Gaetano Montelione
Project type
Capability Research
ABSTRACT The Northeast Structural Genomics Consortium is a NIH-funded pilot project aimed at evaluating the feasibility, costs, economies of scale, and value of structural proteomics. The…

Structural Genomics of Model Eukaryotic Organmisms

Lead Institution
Rutgers University
Principal Investigator
James Aramini
Project type
Capability Research
The primary goal of our pilot project is to develop integrated technologies for high-throughput (htp) protein production and 3D structure determination. Our NESG Consortium has the particular…