Weijun Qian

Collaborative research projects in the PNNL NIH P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

Collaborative research projects in the PNNL NIH P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Multiplex Mass Spectrometric Protein Assays for Obesity

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

The prevalence of overweight and obesity has increased dramatically in recent decades in both children and adults, reaching an epidemic proportion. In order to gain new insights into the…

Technology development in support of NCRR

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Nancy Colton

The Pacific Northwest National Laboratory (PNNL) has built a facility that already stands at the forefront of proteomic research. Moreover, the Center is uniquely poised for future developments. We…

Urinary Proteome Monitoring for Transplant Injury

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Camp

We propose to achieve the objective of identifying novel urinary biomarkers for selected categories of renal transplant injury in two phases. We will first employ a discovery phase to comprehensively…

EDRN Biomarker Reference and Resource Center with the Department of Energy

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The purpose of the Early Detection Research Network (EDRN) Biomarker Reference and Resource Center (BRRC) is to develop a multiplex quantitative MS-based method, based on LC-SRM-MS for simultaneous…

Integrated risk assessment and molecular characterization of pulmonary response
to e-cigarette exposure

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

E-cigarette (e-cig) aerosol/vapor is a complex mixture of the original components of the e-liquid (propylene glycol (PG), vegetable glycerol (VG), nicotine, water, and flavoring additives), and of…

Collaborative Research Projects Supported by the NCRR P41 Resource Center

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Camp

Project type

Large-Scale EMSL Research

The Proteomics Resource Center for Integrative Biology at PNNL was established in 2003 and builds on the unique instrumentation and the infrastructure provided by PNNLs EMSL facility. The mission of…

Center for Application of Advanced Clinical Proteomic Technologies for Cancer (NCI U24; 59963)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The overall objective of the PNNL Clinical Proteome Characterization Center (PCPCC) is to facilitate cancer biomarker development by linking the cancer genotype to the cancer phenotype using detailed…

Agile BioFoundry

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jon Magnuson

This proposed EMSL Resource Owner project, is a sub-project supporting two DOE-EERE-BETO supported PNNL projects: FY16-17 four-national laboratory “Agile BioFoundry” (ABF) seed project and a larger…

Pathways and Critical Regulators of Early Beta-cell Dysfunction in Type 1 Diabetes

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

Type 1 diabetes (T1D) is a complex autoimmune disease. Recent clinical studies show that pancreatic beta-cell dysfunction (e.g., a decline of first phase insulin release) occurs several years before…

Proteomic Studies of Inflammation and the Host Response to Injury

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

Inflammation and The Host Response to Injury, a large scale collaborative research program, is currently funded as a "glue" grant by the National Institute of General Medical Sciences …

Validation and Advanced Development of Emerging Technologies

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Keqi Tang

Develop mass spectrometry (MS) based assays for quantitative biomarker validation with sensitivity and specifically comparable to or better than antibody based immunoassays. The new liquid…

OHSU-PNNL NORTHWEST CO-LABORATORY FOR INTEGRATED OMICS

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Karin Rodland

An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…

Omics Data Generation Center (ODGC) for the Acute to Chronic Pain Signatures (A2CPS)

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

the overall objective of this PNNL-Pittsburgh Omics Data Generation Center component (PP-ODGC) is to develop and implement high throughput omics-based assays for quantifying a broad and diverse set…

Isoform-Specific Quantitative Proteomics Applying N-terminal Enrichment and informatics deconvolution

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

For higher eukaryotic organisms, a single gene can produce multiple protein products (or isoforms) by various mechanisms, such as alternative splicing and post-translational proteolytic processing. …

Pan-Omics Technology Development, Implementation, and Application to GSP Systems Biology Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The BER Genome Science Program aims to understand complex biological and environmental systems across spatial and temporal scales to develop predictive knowledge relevant to DOE mission challenges…

Agile BioFoundry

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Kristin Burnum-Johnson

This proposed EMSL Resource Owner project, is a sub-project supporting two DOE-EERE-BETO supported PNNL projects: FY16-17 four-national laboratory “Agile BioFoundry” (ABF) seed project and a larger…

Reverse Sensitivity Analysis for Identifying Predictive Proteomics Signatures of
Cancer

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

Cancer is a complex disease in which genetic disruptions in cell signaling networks are known to play a significant role. A major aim of cancer systems biology is to build models that can predict the…