Weijun Qian

Center for Application of Advanced Clinical Proteomic Technologies for Cancer (NCI U24; 59963)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Smith

The overall objective of the PNNL Clinical Proteome Characterization Center (PCPCC) is to facilitate cancer biomarker development by linking the cancer genotype to the cancer phenotype using detailed…

Cancer Moonshot - Framingham

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The purpose of the Cancer Moonshot -Framingham project is to apply multiplex quantitative LC-SRM-MS assays for comprehensive, quantitative analysis of longitudinal serum samples associated with head…

Title: Advanced Proteomics and Metabolomics Studies of Type 2 Diabetes and Pre-Diabetes

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Metz

Abstract: In this five year (R21/R33) project we will apply advanced proteomic and metabolomic nanoflow liquid chromatography-Fourier transform ion cyclotron resonance (FTICR) mass spectrometry…

Early Breast Cancer Biomarkers Verification (PNNL Scope #47174, RD Smith's EIF project)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

Our overall objective for studies performed in Years 4 to 6 is to contribute to the assembly of a highly confident protein panel for the early detection of breast cancer by applying the PNNL…

Pan-Omics Technology Development, Implementation, and Application to GSP Systems Biology Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

The BER Genome Science Program aims to understand complex biological and environmental systems across spatial and temporal scales to develop predictive knowledge relevant to DOE mission challenges…

Agile BioFoundry

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Scott Baker

This proposed EMSL Resource Owner project, is a sub-project supporting two DOE-EERE-BETO supported PNNL projects: FY16-17 four-national laboratory “Agile BioFoundry” (ABF) seed project and a larger…

Title: Advanced Proteomics and Metabolomics Studies of Type 2 Diabetes and Pre-Diabetes

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Metz

Abstract: In this five year (R21/R33) project we will apply advanced proteomic and metabolomic nanoflow liquid chromatography-Fourier transform ion cyclotron resonance (FTICR) mass spectrometry…

Collaborative research projects in the PNNL NIH NCRR P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Camp

Collaborative research projects in the PNNL NIH NCRR P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

In type 1 diabetes (T1D) research there remains a critical need for having a systems level understanding of the early stage molecular mechanisms that trigger the specific destruction of pancreatic β…

PNNL Proteomics Chemical Analysis Center for the MoTrPAC (ProMoTr)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

Although the health benefits of physical activity in prevention and mitigation of many chronic diseases have been documented for decades, the molecular mechanisms mediating these health benefits are…

Quantitative Characterization of protein post-translational modifications using mass spectrometry

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

Post-translational protein modifications such as phosphorylation and oxidative modifications play essential roles in the regulation of a variety of biological processes. Increasing evidence suggests…

Development of a Universal Multiplex Assay System fot High-Throughput Biological Applications

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

Recent advances in genomics, proteomics, and metabolomics make the 'omics' technologies powerful discovery-based tools for identifying candidate biomarkers for human diseases; however, it…

Enabling Agile Biomanufacturing with Leading Edge Analytical Biology

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Mark Butcher

This proposed EMSL User project supports a larger multi-lab "Agile Biomanufacturing" project (LBNL, PNNL, SNL). Through the EMSL’s leading edge analytical biology, GC and LC mass…

OHSU-PNNL NORTHWEST CO-LABORATORY FOR INTEGRATED OMICS

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…

Pilot Study on Examination of LIRKO Islets and Serum Using Quantitative Proteomic Approaches

Lead Institution

Joslin Diabetes Center

Principal Investigator

Rohit Kulkarni

A central goal of diabetes research (type 1 and type 2) is to generate large numbers of functional islets or &#61538;-cells for replacement therapy. Therefore, a fundamental knowledge of…

Proteomic Studies of Inflammation and the Host Response to Injury

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

Inflammation and The Host Response to Injury, a large scale collaborative research program, is currently funded as a "glue" grant by the National Institute of General Medical Sciences …

OHSU-PNNL NORTHWEST CO-LABORATORY FOR INTEGRATED OMICS

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Karin Rodland

An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…

Collaborative research projects in the PNNL NIH P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

Collaborative research projects in the PNNL NIH P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

EMSL Science Overview

Weijun Qian

Projects

Center for Application of Advanced Clinical Proteomic Technologies for Cancer (NCI U24; 59963)

Cancer Moonshot - Framingham

Title: Advanced Proteomics and Metabolomics Studies of Type 2 Diabetes and Pre-Diabetes

Early Breast Cancer Biomarkers Verification (PNNL Scope #47174, RD Smith's EIF project)

Pan-Omics Technology Development, Implementation, and Application to GSP Systems Biology Research

Agile BioFoundry

Title: Advanced Proteomics and Metabolomics Studies of Type 2 Diabetes and Pre-Diabetes

Collaborative research projects in the PNNL NIH NCRR P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Regulatory Networks and Biomarkers of Beta-cell Dysfunction and Apoptosis

PNNL Proteomics Chemical Analysis Center for the MoTrPAC (ProMoTr)

Quantitative Characterization of protein post-translational modifications using mass spectrometry

Development of a Universal Multiplex Assay System fot High-Throughput Biological Applications

Enabling Agile Biomanufacturing with Leading Edge Analytical Biology

OHSU-PNNL NORTHWEST CO-LABORATORY FOR INTEGRATED OMICS

Pilot Study on Examination of LIRKO Islets and Serum Using Quantitative Proteomic Approaches

Proteomic Studies of Inflammation and the Host Response to Injury

OHSU-PNNL NORTHWEST CO-LABORATORY FOR INTEGRATED OMICS

Collaborative research projects in the PNNL NIH P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'