Projects

Characterization of Chelsea Humic Acid and Lanchine Kerogen by Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Lead Institution

California Institute of Technology

Principal Investigator

Mamadou Diallo

Project type

Exploratory Research

The primary objective of this research is to develop a molecular level understanding of the uptake of hydrophobic organic compounds by CHA and LK. To achieve this objective, we propose to implement…

Characterization of Bacteriophage T4 Early Gene Proteins

Lead Institution

The Evergreen State College

Principal Investigator

James Neitzel

Project type

Exploratory Research

We have cloned and are purifying a number of early genes from bacteriophage T4. These gene products are usually lethal to E. coli, and in comparison with sequence data bases they have no obvious…

Characterization of Novel Charge Ladders by Capillary Electrophoresis-FTICR Mass Spectrometry

Lead Institution

Harvard University

Principal Investigator

George Whitesides

Project type

Exploratory Research

We believe that CE-ESI-FTICR-MS will be important in the characterization of complex charge ladders of proteins and aminoglycosides. The reaction of Lys- -NH2 groups of bovine carbonic anhydrase II …

Quantifying Human Liver Alcohol Dehydrogenase Isoenzymes

Lead Institution

Stevens Institute of Technology

Principal Investigator

Carol Stone

Project type

Exploratory Research

Researchers report individual variation in ethanol elimination, both within and between ethnic groups, as well as between gender groups. The human alcohol dehydrogenase isoenzymes expressed in liver…

MS Verification of Non Covalent Heterodimer Complex BRAC1-BARD1 Za Binding Sites

Lead Institution

University of Washington

Principal Investigator

Rachel Klevit

Project type

Exploratory Research

The next stage in structure determination of the BRCA1-BARD1 heterodimer complex requires the assignment of aliphatic side chain H-1 and C-13 resonances. Typically, HCCH-TOCSY experiments on fully…

Investigation of Tandem Mass Spectrometry for Identifying Single and Mass-Compensating Double Base Substitutions in p53 and Bacterial Ribosomal PCR Products

Lead Institution

University of South Carolina School of Medicine

Principal Investigator

Alvin Fox

Project type

Exploratory Research

The p53 gene has been recognized in the past few years as an important cell cycle regulatory gene implicated in the production of cancers. One form of the altered gene implicated in cancers…

Characterization of Gold Nanoparticles by FTICR MS/MS

Lead Institution

University of North Carolina

Principal Investigator

Allen Templeton

Project type

Exploratory Research

Gold nano particles have become the subject of great interest due to their unique physical properties which lend them to a wide variety of potential applications such as sensors, optical switches,…

Global and Targeted Proteomic Identification of oxidative modifications.

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Diana Bigelow

Project type

Exploratory Research

Recent research has provided an emerging picture of the significant role of reactive oxygen/nitrogen species (ROS/RNS) and their associated modification of cellular proteins in cellular signaling…

Evaluation of Pore scale porous media effects on reactive transport in groundwater

Lead Institution

University of Texas at Austin

Principal Investigator

Charles Werth

Project type

Exploratory Research

We request use of the EMSL Subsurface Flow and Transport Laboratory?s syringe pumps and work space in order for Thomas Willingham to complete the experimental phase of his Doctoral Research…

TGA Analysis of Synthesized Organic Components of Self-assempbled Monolayers on Mesoporous Silica.

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Robert Wiacek

Project type

Exploratory Research

Nanostructured materials, such as mesoporous silica, may be imparted with desired chemical selectivity and functionality through the use of attached organic functional groups. However, verification…

The use of FESEM

Lead Institution

University of South Carolina

Principal Investigator

Xiao-dong Zhou

Project type

Exploratory Research

It is the intent of this proposal to apply for the access of FESEM. FESEM will be used to characterize the grain size, film thickness and surface morphology of thin films, which are fabricated at…

Profilometry Studies of Printed Electrode Films for Fuel Cell Applications

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Charles Windisch

Project type

Exploratory Research

This study will use profilometry to determine thicknesses of films being deposited on various substrates to be used as electrodes for fuel cell applications. The films are primarily carbon based and…

COST EFFECTIVE ULTRA-THIN PALLADIUM BASED MEMBRANE FOR HYDROGEN SEPARATION AND PURIFICATION

Lead Institution

Innovatek, Inc.

Principal Investigator

Ying Peng

Project type

Exploratory Research

This is a DOE awarded SBIR project and the porject no. is DE-FG02-05ER-84204.InnovaTek Inc. is proposing a novel method to manufacture ultra-thin (less than or equal to 5 µm) palladium-based…

Proteomics of in stiu Biostimulated Sediments

Lead Institution

Lawrence Berkeley National Laboratory

Principal Investigator

Philip Long

Project type

Exploratory Research

The proteomics facility will be used for the detection of peptides/proteins belonging to metal-reducing bacteria in sediment samples from naturally-occurring microbial communities. The bacteria…

Special Projects in Electron Microscopy

Lead Institution

David Heil Associates Corporation

Principal Investigator

James Young

Project type

Exploratory Research

WSU-TriCities course offering for practical training in one or more areas of electron microscopy: TEM, SEM, ultramicrotomy, specimen processing, darkroom procedures and light microscopy. Involves…

High Resolution TEM Images and Electron Diffractions for Gold Nanotubes/Nanorods and Metal Vanadate Nanotubes/Nanorods

Lead Institution

University of Washington

Principal Investigator

Ying Wang

Project type

Exploratory Research

High Resolution TEM Images and Electron Diffractions for Gold Nanotubes/Nanorods and metal Vanadate Nanotubes/Nanorods Ying Wang, Guozhong Cao We have used the template-based methods to prepare…

Compare thermal signature of air-cooled RX2600 node with SprayCool FX2600 node

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kevin Regimbal

Project type

Exploratory Research

As part of the DOE NNSA Energy Smart Data Center (ESDC) project, a full rack of HP RX2600 nodes has been retrofitted to replace the Itanium Heat Sync with Evaporative Spray Cooling caps to evaluate…

Analysis of the Proteome and Transcriptome of In Vivo Salmonella typhimurium Infected Ileum

Lead Institution

Texas A&M University

Principal Investigator

Leslie Adams

Project type

Exploratory Research

The host responses to Salmonella and the Salmonella responses to the host play major roles in the outcome of infection. The present study was aimed to further characterize the molecular pathogenesis…

nickel coating of polmer microbeads

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Ozanich

Project type

Exploratory Research

I would like to coat pure nickel on 20-30 micron diameter spherical polymer beads (polystyrene/divinylbenzene). Layer thickness and uniformity are not critical, but desire thin (< few microns)…

Nanostructured Catalysts for Fuel Cells

Lead Institution

University of Alabama

Principal Investigator

Christoffer Turner

Project type

Exploratory Research

Our goal is to understand, at a fundamental level, the interactions in a platinum/graphite catalyst used as an anode of a PEM fuel cell and its influence on CO and H2 oxidation reactions. The metal…