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Projects

As a scientific user facility, the Environmental Molecular Sciences Laboratory (EMSL) provides expertise, instrumentation, and resources to 250 projects each year. 

EMSL projects displayed on the EMSL web site project page reflect project abstracts and information migrated to this page before April 30, 2024. To review current and past EMSL user projects, visit EMSL Science Central.™ 

 

Performance Prediction and Process Attribution for Additive Manufacturing

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Christopher Barrett
The proposed work seeks to develop a modeling-prescribed measurement strategy to generate the data necessary to build a finite element model from which an additively manufactured objects’ performance…

Structure of the RPE65-CCT folding intermediate

Lead Institution
University of Utah
Principal Investigator
Peter Shen
The retinal pigment epithelium 65 kDa protein (RPE65) plays an essential role in human vision by catalyzing the conversion of all-trans retinol esters to 11-cis retinol. This reaction is a key step…

Mechanism of RNA processing by the Dicer enzyme

Lead Institution
University of Utah
Principal Investigator
Peter Shen
We aim to achieve an atomic-resolution understanding of how Dicer recognizes and processes its RNA substrates. We recently solved a 6.8 Å resolution cryo-EM structure of the Drosophila Dicer-2 (dmDcr…

Structure and mechanism of neurotransmitter-gated ion channels

Lead Institution
Oregon Health & Science University
Principal Investigator
Eric Gouaux
The objectives of this research are to elucidate the structures of mammalian neurotransmitter receptors by single particle cryo-EM in multiple distinct conformational states in which the receptors…

Computational characterization of FeFe-Hydrogenase catalytic species

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Simone Raugei
We propose to use EMSL supercomputing resources to gain a molecular level understanding of the catalytic mechanism of the interconversion of H2 into electrons and protons and vice versa at the active…

PNCC Database Capability Development

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
James Evans
This is a capability development proposal to work on the data transfer between PNCC in Oregon and MyEMSL.

Structure, function and aggregation of the lens alpha-crystallins

Lead Institution
Portland State University
Principal Investigator
Steve Reichow
We are applying emerging methods in single particle CryoEM to advance our understanding the molecular mechanisms leading to cataract formation (the leading cause of blindness in the world). The focus…

Cryo-EM studies of the human biogenic amine transporters

Lead Institution
Oregon Health & Science University
Principal Investigator
Eric Gouaux
The aims of the proposed research are to elucidate the first structure of the human dopamine transporter (hDAT) as well as to determine multiple structures of the human serotonin transporter (hSERT)…

Pacific Northwest Advanced Compound Identification Core

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
The capability to chemically identify thousands of metabolites and other chemicals in clinical samples will revolutionize the search for environmental, dietary, and metabolic determinants of disease…

Betavoltaics from COTS: Power for Years

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Lance Hubbard
Overwhelmingly, betavoltaics’ (BV) long-lasting power opens a broad range of applications which are not currently available. The birth of very low power electronics has opened up a market for the…