Projects

Micro-Mechanical Characterization of Magnesium Alloys

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Aashish Rohatgi

Project type

Exploratory Research

The goal of this proposal is to understand the effects of various microstructural features on the deformation and strengthening mechanisms in magnesium alloys. It being the lightest structural metal,…

First Principles Modeling Of Oxygen Reduction at Complex Perovskite Surfaces for Fuel Cell and Gas Separation Applications

Lead Institution

Institute for Solid State Physics, The University of Latvia

Principal Investigator

Jevgenijs Kotomins

Project type

Exploratory Research

Using DFT first principles method implemented in VASP 5.0 computer code for large scale parallel calculations, we will study the atomic, electronic structure and physico-chemical properties of oxygen…

Hydrogen Bond Networks

Lead Institution

University of Minnesota

Principal Investigator

Steven Kass

Project type

Exploratory Research

Nature employs hydrogen bonds to organize biomolecular structures and optimize the catalytic ability of enzymes. The effects of hydrogen bond networks are relatively unknown and will be explored by…

Magnesium NMR of DNA Repair Proteins

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Andrew Lipton

Project type

Exploratory Research

The chemistry central to the function of the DNA repair proteins apurinic/apyrimidic endonuclease 1 (APE1) and polymerase beta (pol beta) is the chemistry of water activated by a magnesium ion. …

Characterization of Effector and Host Proteins Involved in Host-Pathogen Interactions

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

Project type

Exploratory Research

The multiple mechanisms by which pathogenic enterobacteria of the genus Salmonella infect their host indicate a complex host-pathogen relationship. The pathogen secretes dozens of proteins, termed &…

Intermediate-scale Experiments to Test a Novel Vapor-phase Tomography Method

Lead Institution

University of Arizona

Principal Investigator

Jon Mainhagu

Project type

Exploratory Research

The objective of this experimental study, funded by the DOE Office of Groundwater and Soil Remediation (EM-32), is to evaluate a new vapor-phase tomography method by conducting a series of…

Determination of Water Saturation in Relatively Dry and Desiccated Porous Media using Gas-phase Partitioning Tracer Tests

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Michael Truex

Project type

Exploratory Research

Soil desiccation (drying), involving water evaporation induced by dry air injection and extraction, is a potentially robust remediation process to slow migration of inorganic or radionuclide…

Ion-Beam and X-ray Chemical Analysis of MOxNy (M=Zr,Ti) Thin Films

Lead Institution

University of Texas at El Paso

Principal Investigator

Chintalapalle Ramana

Project type

Exploratory Research

The development of new/novel functional materials, which can exhibit superior structural and electronic properties at the reduced dimensions, for application in energy technologies is a challenging…

Computer-aided Design of a Catalytic Proton Channel

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Wendy Shaw

Project type

Exploratory Research

The objective of the proposed research is to incorporate a rationally designed proton channel into homogeneous catalysts using advanced enzyme design methodology combined with superior molecular…

Effect of Structure and Impurities on Charge Transfer Reactions in Solid State Electrochemical Devices

Lead Institution

Boston University

Principal Investigator

Srikanth Gopalan

Project type

Exploratory Research

We are investigating epitaxial thin films of SOFC cathodes on single crystal substrates and polycrystalline thin films on yttria doped zirconia substrates. The goal is to use these films to perform…

Parallel Reactive Transport Modeling of Radioactive Waste Form Weathering using the STORM Code

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Diana Bacon

Project type

Exploratory Research

The STORM parallel reactive transport code has been developed to simulate the geochemical weathering of radioactive waste forms after disposal in a subsurface facility. STORM simulates unsaturated…

Physical properties of natural siliceous sinters from thermal springs

Lead Institution

University of Montana

Principal Investigator

Nancy Hinman

Project type

Exploratory Research

We propose a study of physical properties of naturally occurring silica minerals to examine the ultrastructure of silica minerals in hydrothermal systems. Our work also will include a study of the…

CASMGS Consortium (PNNL Scope #43606)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

James Amonette

Project type

Exploratory Research

The CASMGS Consortium will provide the information and technology necessary to develop, analyze and implement carbon sequestration strategies. Work authorization text added 8/11/05: The United…

Cardiac Metabolism and Protein Synthesis during Extracorporeal Life Support

Lead Institution

Seattle Children's Research Institute

Principal Investigator

Michael Portman

Project type

Exploratory Research

Mechanical Circulatory Support (MCS) in the form of cardiopulmonary bypass (CPB) is commonly used for infants and children. Extracorporeal life support (ECLS) also a form of MCS remains the primary…

Global Analysis of Histone Post-translational Modifications Specific to Rett Syndrome using 2D RPLC/WCX-HILIC for Online Top-down Mass Spectrometry

Lead Institution

University of Edinburgh

Principal Investigator

Patrick Langridge-Smith

Project type

Exploratory Research

Epigenetics is a rapidly expanding field in biology, due to many technological breakthroughs and a greater understanding of the mechanisms of gene regulation. The location of epigenetic markers such…

Carbon Nanotube-Intestinal Barrier Cell Interactions, Absorption, and Dosimetry

Lead Institution

Indiana University School of Medicine

Principal Investigator

Frank Witzmann

Project type

Exploratory Research

Carbon nanotubes (CNT) are important components of the rapidly expanding nanotechnology field. Due to their size and unique chemical, electrical, mechanical, and thermal properties, they have found…

Electron-Acceptor Fullerene Materials for Organic Photovoltaics: Electronic Properties in Gas-Phase, Solution, Solid-Phase and in Donor/Acceptor Blends

Lead Institution

Colorado State University

Principal Investigator

Steven Strauss

Project type

Exploratory Research

This project will focus on understanding of the fundamental relationships between molecular structures of perfluoroalkylated fullerenes (PFAFs) and their electronic properties in the gas-phase, in…

An integrated top-down / bottom-up method to identify disease related antibodies

Lead Institution

Erasmus University Medical Center, Rotterdam

Principal Investigator

Theo Luider

Project type

Exploratory Research

We describe the discovery of a new class of biomarkers derived from immunoglobulins using mass spectrometry. We previously investigated this approach in model systems with bottom-up proteomics, and…

Comparative analysis of the Mosquito Vector and Vertebrate Host of Dengue Virus: Characterizing the Membrane Structures Required for Virus Replication

Lead Institution

Purdue University

Principal Investigator

Rushika Perera

Project type

Exploratory Research

This proposal is submitted in response to EMSL's science theme "Biological Interactions and dynamics." Our objective is to use high-resolution mass spectrometry and time-lapse single…

Leveraging rRNA pseudouridylation defects to identify operational programmed -1 ribosomal frameshift signals in yeast, mice and human cells.

Lead Institution

University of Maryland, College Park

Principal Investigator

Jonathan Dinman

Project type

Exploratory Research

Programmed -1 ribosomal frameshifting (-1 PRF) is a molecular mechanism in which cis-acting signals direct a fraction of elongating ribosomes to slip by 1 nucleotide in the 5-prime direction along an…