Karin Rodland

Quantitative Proteomics-based Prostate Cancer Prediction Models for African American and Caucasian American Patients

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

In this research project, the Pacific Northwest National Laboratory (PNNL) research team will support the project by conducting quantitative proteomics analysis using mass spectrometry to identify…

CPTAC Proteome Characterization Center

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The overall objective of the PNNL Proteome Characterization Center (PCC) is to comprehensively characterize human tumor samples provided by the National Cancer Institute (NCI), and to integrate the…

EDRN Biomarker Reference and Resource Center with the Department of Energy

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The purpose of the Early Detection Research Network (EDRN) Biomarker Reference and Resource Center (BRRC) is to develop a multiplex quantitative MS-based method, based on LC-SRM-MS for simultaneous…

Massively Parallel Molecular Profiling of Breast Cancer

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Smith

Molecular profiling of breast cancer into subcategories based on functional ER expression and amplification of HER2 has significantly enhanced our understanding of the disease, and has pointed the…

Cancer Moonshot - Framingham

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The purpose of the Cancer Moonshot -Framingham projects is to perform multiplexed, quantitative LC-MS analysis of longitudinal serum samples associated with head and neck cancer, B-cell lymphoma,…

Undiagnosed Diseases Network Metabolomics Core

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Metz

A state of the art metabolomics core will be a vital part of the Undiagnosed Diseases Network (UDN). However, in order for the UDN to realize it’s the full potential it is essential that the…

OHSU-PNNL Northwest Co-laboratory for Integrated Omics

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…

OHSU-PNNL NORTHWEST CO-LABORATORY FOR INTEGRATED OMICS

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Karin Rodland

An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…

Plan for validating and improving identification results in the Human Plasma Proteome Project (HPPP)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Karin Rodland

Project type

Exploratory Research

We would like to propose a special project in the category ?Comparison of results within sets of technologies?, and invite interested labs to participate in the pilot phase. The project…

EDRN Biomarker Reference and Resource Center with the Department of Energy

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The purpose of the Early Detection Research Network (EDRN) Biomarker Reference and Resource Center (BRRC) is to develop a multiplex quantitative MS-based method, based on LC-SRM-MS for simultaneous…

OHSU-PNNL NORTHWEST CO-LABORATORY FOR INTEGRATED OMICS

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Karin Rodland

An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…

CPTAC Proteome Characterization Center

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The overall objective of the PNNL Proteome Characterization Center (PCC) is to integrate genomic information with proteomic technologies to comprehensively characterize the proteome and post…

Identifying Targets for Therapeutic Interventions using Proteomic Technology

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

Project type

Exploratory Research

This proposal will utilize new comprehensive and quantitative proteomic technologies and related capabilities developed at PNNL to identify targets for therapeutic intervention for Salmonella…

OHSU-PNNL NORTHWEST CO-LABORATORY FOR INTEGRATED OMICS

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Karin Rodland

An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…

Identifying Targets for Therapeutic Interventions using Proteomic Technology

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

This proposal will utilize new comprehensive and quantitative proteomic technologies and related capabilities developed at PNNL to identify targets for therapeutic intervention for Salmonella…

PTRC Proteogenomic Translational Research Center

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Karin Rodland

Due to the complexity of signaling and sequence modifications in cancer, predictions of pathway regulation and dependence based upon genomic data alone is challenging. This research proposal will…

Characterization of a putative truncated Calcium-sensing receptor form human ovarian tumors

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Karin Rodland

Project type

Exploratory Research

Rationale: We have determined that the wild-type calcium-sensing receptor [CaR] plays an important role in regulating the proliferative behavior of normal ovarian surface epithelial cells, the cell…

Cancer Moonshot - Framingham

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The purpose of the Cancer Moonshot -Framingham project is to apply multiplex quantitative LC-SRM-MS assays for comprehensive, quantitative analysis of longitudinal serum samples associated with head…

WRI Breast Cancer

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The aim of this pilot project is to obtain comprehensive data on protein expression from breast tumor samples in the WRI tissue repository from patients that are stratified by having negative or…

PTRC Proteogenomic Translational Research Center

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Paul Piehowski

Due to the complexity of signaling and sequence modifications in cancer, predictions of pathway regulation and dependence based upon genomic data alone is challenging. This research proposal will…

A proteomic analysis of the dynamic response to hydrocodone administration in humans

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Joshua Adkins

During Operations Iraqi Freedom and Enduring Freedom, our war-fighters have been subject to debilitating physical and psychological trauma. These injuries have correlated with increased substance…

OHSU-PNNL NORTHWEST CO-LABORATORY FOR INTEGRATED OMICS

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Jon Jacobs

An essential component of the OHSU-PNNL Northwest CoLaboratory for Integrated Omics (CoLab) is the collaborative pursuit of joint research projects that leverage the compelling biomedical model…

EDRN Biomarker Reference and Resource Center with the Department of Energy

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The purpose of the Early Detection Research Network (EDRN) Biomarker Reference and Resource Center (BRRC) is to develop a multiplex quantitative MS-based method, based on LC-SRM-MS for simultaneous…

Cancer Moonshot - Framingham

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The purpose of the Cancer Moonshot -Framingham project is to continue finishing analysis of ~1300 serum samples with applying multiplex quantitative LC-SRM-MS assays for comprehensive, quantitative…

Center for Application of Advanced Clinical Proteomic Technologies for Cancer (NCI U24; 59963)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The overall objective of the PNNL Clinical Proteome Characterization Center (PCPCC) is to facilitate cancer biomarker development by linking the cancer genotype to the cancer phenotype using detailed…

EDRN Biomarker Reference and Resource Center with the Department of Energy

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The purpose of the Early Detection Research Network (EDRN) Biomarker Reference and Resource Center (BRRC) is to develop a multiplex quantitative MS-based method, based on LC-SRM-MS for simultaneous…

Massively Parallel Molecular Profiling of Breast Cancer

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Smith

Molecular profiling of breast cancer into subcategories based on functional ER expression and amplification of HER2 has significantly enhanced our understanding of the disease, and has pointed the…

CPTAC Proteome Characterization Center

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The overall objective of the PNNL Proteome Characterization Center (PCC) is to integrate genomic information with proteomic technologies to comprehensively characterize the proteome and post…

EDRN Biomarker Reference and Resource Center with the Department of Energy

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

The purpose of the Early Detection Research Network (EDRN) Biomarker Reference and Resource Center (BRRC) is to develop a multiplex quantitative MS-based method, based on LC-SRM-MS for simultaneous…

Molecular analysis of exRNA carrier subclasses

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

As a consortium site, PNNL will perform proteomic and lipidomic analysis of exosome RNA (exRNA) carrier subclass samples generated using differential centrifugation, density gradient centrifugation,…

Center for Application of Advanced Clinical Proteomic Technologies for Cancer (NCI U24; 59963)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Richard Smith

The overall objective of the PNNL Clinical Proteome Characterization Center (PCPCC) is to facilitate cancer biomarker development by linking the cancer genotype to the cancer phenotype using detailed…

PTRC Proteogenomic Translational Research Center

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Paul Piehowski

Due to the complexity of signaling and sequence modifications in cancer, predictions of pathway regulation and dependence based upon genomic data alone is challenging. This research proposal will…

Projects