Projects

Thermochemical Kinetics of Pyrolysis and Oxidation of Biodiesel for Predictive Combustion Modeling

Lead Institution

Princeton University

Principal Investigator

Emily Carter

Project type

Exploratory Research

The increasing sensitivity in the U.S. over the dependence on foreign sources of crude oil for energy production, as well as the need to limit the release of greenhouse gases into the atmosphere, is…

Transcriptional and epigenetic regulation following ionizing radiation exposure in a skin model system

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Stenoien

Project type

Exploratory Research

Dynamic post-translational modifications (PTMs) occurring on histones play essential roles in regulating transcription of specific target genes and in the epigenetic reprogramming occurring during…

Modeling Conduction in Organic Solar Cells

Lead Institution

University of California, Los Angeles

Principal Investigator

Daniel Neuhauser

Project type

Exploratory Research

We propose to model conduction in organic solar cells. Organic solar cells have promise in the manufacturing of efficient, inexpensive solar devices, which are essential to our energy future. A…

Bimetallic Nanoparticle Catalysts Based on Copper for the Synthesis of Methanol from CO2 and H2.

Lead Institution

Western Washington University

Principal Investigator

John Gilbertson

Project type

Exploratory Research

Carbon dioxide is a known greenhouse gas and contributor to global warming, while methanol is a convenient chemical feedstock, H2 storage medium, and alternative fuel. The synthesis of methanol via…

Density Functional Theory Calculations on Nucleation and Nanoparticles in the Fe-O-H system

Lead Institution

University of Texas at El Paso

Principal Investigator

James Kubicki

Project type

Exploratory Research

Molecular simulation of nanoscale and larger processes has generally required the use of classical force fields because quantum calculations are too computationally demanding and often do not scale…

Computational Mechanistic Studies of Water Oxidation by Ru Based Catalysts

Lead Institution

Washington State University

Principal Investigator

Aurora Clark

Project type

Exploratory Research

The development of catalysts which can produce H2 or other fuels and are made from earth-abundant materials is dependent upon the fundamental nature of the catalytic reactions and is closely linked…

Structural Proteomics: annotating the genome using 3D structure

Lead Institution

University of Toronto

Principal Investigator

Cheryl Arrowsmith

Project type

Capability Research

We are applying for NMR spectrometer time at EMSL as a continuation of our structural proteomics project. Structural proteomics is based on the premise that a protein's biochemical function is…

High-Field Aluminum-27 Solid-State NMR Studies of Catalytic Zeolites and Weathered Clay Materials

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Karl Mueller

Project type

Capability Research

We propose the study of a number of zeolite and weathered clay materials using high-field aluminum-27 solid-state NMR spectroscopy. In each of two sets of materials, acquisition of spectra using…

Structural genomics of eukaryotic model organisms

Lead Institution

Rutgers University

Principal Investigator

Gaetano Montelione

Project type

Capability Research

ABSTRACT The Northeast Structural Genomics Consortium is a NIH-funded pilot project aimed at evaluating the feasibility, costs, economies of scale, and value of structural proteomics. The…

Structure of the PR domain of RIZ1 tumor suppressor

Lead Institution

The Burnham Institute

Principal Investigator

Kathryn Ely

Project type

Capability Research

RIZ1 is a PR domain containing histone lysine methyltransferase and tumor suppressor activity that provides a link between dietary and genetic causes of cancer. We plan to determine the structure of…

Investigating Molecular Recognition and Biological Function at Interfaces Using Antimicrobial and Biomineralization Peptides

Lead Institution

Hamilton College

Principal Investigator

Myriam Cotten

Project type

Capability Research

My research plans reflect my fundamental interest in the principles underlying the biological function and the mechanisms of action of peptides active at interfaces. Complementary solid state Nuclear…

Structure determination of membrane proteins

Lead Institution

Case Western Reserve University

Principal Investigator

Frank Soennichsen

Project type

Capability Research

Membrane proteins, although representing about one third of encoded proteins, are structurally undercharacterized. Yet, with the recent improvements in field and experiments, solution NMR…

Structure determination of leucine-rich amelogenin protein adsorbed to hydroxyapatite using computational structure prediction

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Wendy Shaw

Project type

Exploratory Research

The formation of biogenic materials requires the interaction of organic molecules with the mineral phase. In forming dental enamel, the mineralization of hydroxyapatite (HAp) is largely attributed to…

Determination of the peptide-binding sites on the bacterial chaperone protein SecB

Lead Institution

University of Missouri - Columbia

Principal Investigator

Linda Randall

Project type

Exploratory Research

The chaperone protein SecB is required for the efficient export of certain proteins across the periplasmic membrane of E.coli. SecB promotes export by binding to the proteins and delivering them to…

The Role of Lipid Phosphatase Sac1 in the Organization of the Cortical/Tubular Endoplasmic Reticulum in Yeast

Lead Institution

Oregon Health & Science University

Principal Investigator

Peter Mayinger

Project type

Exploratory Research

The endoplasmic reticulum (ER) is a continuous membrane system but consists of various domains that perform different functions. Distinct ER regions are composed of sheets and tubules, which differ…

Bioinspired electrocatalysts for small molecule activation.

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Wendy Shaw

Project type

Exploratory Research

The proposed EMSL research is in support of three DOE Basic Energy Sciences research programs that focus on the development of new classes of electrocatalysts for important energy storage and energy…

Nanoparticle / PDMS-based Microfluidic Device for Environmental Monitoring

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jun Wang

Project type

Exploratory Research

This proposal is to develop nanoparticle-based microfluidic chips for multiplexed detection of environmental biomarkers. We will choose the poly(dimethylsiloxane) (PDMS) to fabricate the microfluidic…

NMR structural studies of apoAI/preb-HDL particles

Lead Institution

Wayne State University

Principal Investigator

Jianjun Wang

Project type

Capability Research

Apolipoprotein A-I (apoAI) is a 243-residue exchangeable apolipoprotein that plays a key role in clearing the ?bad cholesterol? from the human blood stream. ApoAI is the most abundant protein…

Characterize the Thermodynamic Forces of Decomposing a Cellulose Microfibril

Lead Institution

University of California, Berkeley

Principal Investigator

Jhih-Wei Chu

Project type

Exploratory Research

To develop viable technologies for the enzymatic decomposition and conversion of cellulosic materials into fuels, mechanistic understanding of the molecular processes that are involved is in urgent…

High-throughput sequence analysis for communities and environmental sample metagenomics

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Christopher Oehmen

Project type

Capability Research

Metagenomes and multiple genome samples include environmental samples from soil and water, community samples involving multiple species (such as human or termite gut) and others. DOE has recognized…