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Projects

As a scientific user facility, the Environmental Molecular Sciences Laboratory (EMSL) provides expertise, instrumentation, and resources to 250 projects each year. 

EMSL projects displayed on the EMSL web site project page reflect project abstracts and information migrated to this page before April 30, 2024. To review current and past EMSL user projects, visit EMSL Science Central.™ 

 

Analysis of Spent Free Electron Laser Photocathodes

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Wayne Hess
Project type
Limited Scope
This project will use existing capabilities to characterize expired photocathode materials. We will conduct post-mortem investigations of used (expired) photocathodes from JLab to determine…

Solvent Effects on Fluorescence Lifetimes of Uranyl Salts

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Paul Gassman
Project type
Limited Scope
We propose to utilize the EMSL cryogenic laser induced fluorescence (CLIFS) capability in laboratory 1507 for the purpose of quantifying the effects of solvents on fluorescence lifetimes of various…

Making Isoprene from Biomass Material using Bacillus Species

Lead Institution
Washington State University Tri-Cities
Principal Investigator
Birgitte Ahring
Project type
Limited Scope
Isoprene, also known as 2-methyl-1, 3-butadiene, is a volatile, five-carbon, pure hydrocarbon. Isoprene is derived from biomass through a biochemical process and can be utilized as a fossil fuel…

The Influence of Adsorbates on the Interfacial Properties of Fe3O4(001)

Lead Institution
Vienna University of Technology
Principal Investigator
Ulrike Diebold
Project type
Limited Scope
Magnetite (Fe3O4) currently attracts much attention from the spintronics research community because it is a rare example of a room temperature half-metal. However, the most important Fe3O4 surfaces…

Laser Micro-dissection of a Novel Cytoplasmic Structure in Cancer Stem Cells

Lead Institution
Fred Hutchinson Cancer Research Center
Principal Investigator
David Hockenbery
Project type
Limited Scope
Laser Micro-dissection of a Novel Cytoplasmic Structure in Cancer Stem Cells We have identified a peri-nuclear fibrillar-granular structure in breast and colon cancer cell lines by transmission…

MHC presented peptide quantitation: mass spectrometry methods development

Lead Institution
University of Tennessee
Principal Investigator
Heather Smallwood
Project type
Limited Scope
The phenomenon of immunodominance has been observed in B cell, CD4+ T cell and CD8+ T cell antigen-specific responses in virtually all types of infection and in tumor immunity model. It is still…

Photometric response of anion selective chromoionophores

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Shane Peper
Project type
Limited Scope
UV-Vis absorbance and fluorescence spectrophotometeries are required to test the photometric response of some halide selective chromoionophores.

Chalcogenide Surface Science

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Bradley Johnson
Project type
Limited Scope
The objective of this work is to use XPS to study the surface chemistry of IR transparent chalcogenide fibers that have undergone photo-induced and/or opto-mechanical failures. Raytheon Missile…

Study of temperature-sensitive mutants of yeast guanylate kinase

Lead Institution
Washington State University
Principal Investigator
Ping Ye
Project type
Limited Scope
The ability to switch genes on and off spatially and temporally is important for understanding individual gene function in complex biological processes. Despite the fact that a variety of conditional…

Trout brain neuropeptidome

Lead Institution
University of Idaho
Principal Investigator
James Nagler
Project type
Limited Scope
We have a currently funded National Science Foundation (NSF) grant "Modeling the salmonid hypothalamus-pituitary-gonad axis" that is coming to an end and our intent is to renew this project…

Rapid access to cell culture facilities

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Weber
Project type
Limited Scope
I have a masters student that needs access to cell culture facilities during the move from 331 to BSF.

Insights into the RNase A mechanism

Lead Institution
University of California, San Diego
Principal Investigator
John Weare
Project type
Limited Scope
mRNA-polymers copied from DNA are degraded after transcription by cleavage of diphosphate bonds in the RNA backbone by Ribonuclease enzymes (RNase) as part of cell metabolism. In our study we employ…

Analysis of Leishmania phosphoprotein isoforms

Lead Institution
Institut Pasteur, Paris, France
Principal Investigator
Gerald Spaeth
Project type
Limited Scope
Our laboratory applies quantitative phosphoproteomics to investigate signaling networks underlying the pathogenicity of the protozoan parasite Leishmania, which causes severe human diseases around…