Projects

As a scientific user facility, the Environmental Molecular Sciences Laboratory (EMSL) provides expertise, instrumentation, and resources to 250 projects each year.

EMSL projects displayed on the EMSL web site project page reflect project abstracts and information migrated to this page before April 30, 2024. To review current and past EMSL user projects, visit EMSL Science Central.™

Mechanistic Insights into Stress Corrosion Cracking through Fundamental Studies of Selective Oxidation Mechanisms

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Daniel Schreiber

Materials degradation and failure in hostile environments are critical issues affecting current and future generations of power generation systems. In this research, we seek to elucidate the…

Investigating interactions and aggregate structures of boehmite particles toward understanding of bulk rheology

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Jaehun Chun

The aim of the proposed research is to understand unique particle interactions in tank waste relevant systems from chemical physics at solid-liquid interfaces, and to determine how those interactions…

Combining isotopic measurements using in situ Liquid SIMS and in situ TEM to determine the mechanism and kinetics of Li ion mobility in SEI layers

Lead Institution

Environmental Molecular Sciences Laboratory

Principal Investigator

Zihua Zhu

Li ion batteries are now indispensably used as energy storage devices for portable electronics, electric vehicles, and are starting to enter the market of the renewable energies. The rechargeable…

Integration of Substrate Oxidation with Protein Synthesis and Cellular Signaling in a Complex Biological System

Lead Institution

Seattle Children's Research Institute

Principal Investigator

Michael Portman

These investigations will explore the complex interactions involved in cellular metabolism, protein synthesis, and cell signaling. We will use complex models to link intra-cellular regulatory…

Heteroepitaxial nucleation and growth of complex coatings at mineral/water interfaces

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Sebastien Kerisit

All realistic mineral surfaces in natural waters can be expected to be coated, and their reactive properties influenced by the presence of coatings. Heteroepitaxial growth is the templated growth of…

An In-situ Investigation of a-AlOOH Dissolution under High pH Conditions

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Edgar Buck

The dissolution and precipitation of gibbsite [a-Al(OH)3] and boehmite [a-AlOOH] is of prime importance to the final disposition of high-level nuclear waste (HLW) stored at the Hanford Site. The high…

Simulations of Complex Chemistry at Mineral/Fluid Interfaces: Development and application of Petascale/Exaflop First Principle Simulation Technology

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Eric Bylaska

Novel first principle methods of simulations will be developed and applied to computationally intractable geochemical problems such as: i) Interpretations of structure, reactivity and electron…

Probing complex microbiomes using mass spectrometry and sequencing capabilities to understand how microbiomes are influenced by their environment

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Stephen Callister

This is a resource owner proposal as part of the MinT LDRD Initiative. The objective of this proposal is the development of sequencing and mass spectrometry capabilities to support research into how…

Advancing ecosystem understanding of carbon turnover and storage through molecular characterization

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kirsten Hofmockel

The coupling between concurrently changing carbon (C) and nitrogen (N) cycles remains a key uncertainty in understanding feedbacks between the terrestrial C cycle and climate change. Decades of…

Decommissioning of protein phosphatase 2A holoenzymes

Lead Institution

University of Wisconsin, Madison

Principal Investigator

Yongna Xing

Protein phosphatase 2A (PP2A) is a major tumor suppressor and plays a critical role in many essential cellular processes via formation of diverse heterotrimeric holoenzymes. Each holoenzyme contains…

Understanding the Molecular Mechanisms of P2X7 Receptor Signal Transduction

Lead Institution

Oregon Health & Science University

Principal Investigator

Steven Mansoor

P2X receptors are trimeric, non-selective cation channels activated by extracellular ATP to modulate processes in the cardiovascular and immune systems. P2X7 receptor, the most structurally and…

Visualizing the molecular mechanisms of synaptic vesicle transporters

Lead Institution

University of Pittsburgh

Principal Investigator

Jonathan Coleman

Approximately 1% of the population experiences seizures, making epilepsy one of the most common neurological disorders. The impact on the livelihood of an individual is, in many ways unfathomable and…

Looking at the high-resolution structure of IRE1 inside cells using sub-tomogram averaging

Lead Institution

California Institute of Technology

Principal Investigator

Grant Jensen

The primary objective of our proposal is to image IRE1 foci using high-resolution cellular electron cryo-tomography (ECT). IRE1 is a member of the unfolded protein response (UPR). The UPR is an…

Determining structural mechanisms of transporters and signaling networks in cellular stress responses

Lead Institution

University of Arizona

Principal Investigator

Thomas Tomasiak

Rapidly dividing or invasive cells tied to diseases such as cancer, fungal or bacterial infection require responses that enable their survival during nutrient deprivation and drug therapy. Tightly…

Stream Floc Processes Involving Ferrous Iron Oxidation in a Riparian Wetland

Lead Institution

Savannah River National Laboratory

Principal Investigator

Daniel Kaplan

Project type

Limited Scope

One of the defining characteristics of wetlands is the permanent or intermittent presence of standing water. They provide many critical ecosystem services, including water storage, and fertilizer and…

Palmitoylation is a dynamic regulator of plant receptor localization and function

Lead Institution

University of Missouri - Columbia

Principal Investigator

Gary Stacey

Project type

Large-Scale EMSL Research

Recent data indicate that competition between plant plasma membrane (PM) receptor palmitoylation and autophosphorylation defines inactive and active states, respectively. Hence, for any given…

CryoEM Studies of AAV Rep-DNA complexes underlying AAV life cycle.

Lead Institution

Virginia Commonwealth University

Principal Investigator

Carlos Escalante

Adeno-associated virus (AAV) non-structural Rep proteins carry out all DNA transactions that regulate the AAV life cycle. They share two multifunctional domains: an N-terminal origin binding/nicking…

The formation of pyrite and incorporation of trace element and water inclusions: a view from modern depositional settings

Lead Institution

University of Toronto

Principal Investigator

Daniel Gregory

Project type

Large-Scale EMSL Research

This project utilizes atom probe tomography (APT) and transmission electron microscopy (TEM) to investigate microcrystalline masses of pyrite (FeS2) at the nano-scale. These analyses will be…

Investigations of host-pathogen interactions and cellular structures with cryo-electron microscopy

Lead Institution

University of Wisconsin, Madison

Principal Investigator

Elizabeth Wright

The Wright laboratory uses cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) to study biological problems in structural cell biology and infectious disease. We are…

In situ tracking of carbon flow through the soil microbiome

Lead Institution

Institute of Microbiology of the CAS

Principal Investigator

Petr Baldrian

Project type

Large-Scale EMSL Research

Forest soils represent an environment with high carbon (C) stocks and important hotspots of C turnover and microorganisms are the most important actors in this process. The understanding of the C…

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