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Kristin Burnum-Johnson

Institution
Environmental Molecular Sciences Laboratory

Projects

Agile Biofoundry FY24-25

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Nathalie Munoz Munoz
This proposed EMSL Staff time proposal assists the DOE-EERE-BETO supported PNNL project: FY24-25 seven-national laboratory Agile BioFoundry (https://agilebiofoundry.org/). PNNL’s effort for this…

Application of High-Throughput Proteomics

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Mary Lipton
The understanding of how cells function at the systems level will greatly benefit from the development of new approaches capable of making global measurements of protein expression (proteome). The…

Omics Data Integration via Interpretable Machine Learning Models

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Lisa Bramer
Often, the ultimate motivation for the generation of omics data for an experiment is a better understanding of the biological system; the generation of multiple 'omics datasets for the same…

Collaborative Research Projects Supported by the NCRR P41 Resource Center

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Camp
Project type
Large-Scale EMSL Research
The Proteomics Resource Center for Integrative Biology at PNNL was established in 2003 and builds on the unique instrumentation and the infrastructure provided by PNNLs EMSL facility. The mission of…

Single Cell Resolution Omics Analysis of T1D islets

Lead Institution
National Institutes of Health
Principal Investigator
Charles Ansong
Type 1 diabetes mellitus (T1D) is a chronic disease resulting from the autoimmune destruction of insulin-producing pancreatic beta cells. In addition to evolving ideas about the role of beta cells in…

Next Generation Clinical Proteomics to Target Human Health Challenges

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
Changes in protein expression revealed by proteomics technologies will potentially revolutionize the global understanding of human diseases by characterizing both distinct disease states and disease…

Agile BioFoundry

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Kristin Burnum-Johnson
This proposed EMSL Resource Owner project, is a sub-project supporting two DOE-EERE-BETO supported PNNL projects: FY16-17 four-national laboratory “Agile BioFoundry” (ABF) seed project and a larger…

Interpretable Machine Learning for Multivariate Omics Data Analysis

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Lisa Bramer
Often, the ultimate motivation for the generation of omics data for an experiment is a better understanding of an observed phenotype of a biological system and the effect of perturbations on the…

Dopamine Replacement Therapy and Parkinson's Disease

Lead Institution
Uppsala University
Principal Investigator
Malin Andersson
Project type
Exploratory Research
Dopamine (DA) replacement therapy with L-3,4-dihydroxyphenylalanine (L-DOPA) is currently the most efficient pharmacotherapy for patients with Parkinson's disease (PD), but with disease…

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…

Next Generation Clinical Proteomics to Target Human Health Challenges

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jon Jacobs
Changes in protein expression revealed by proteomics technologies will potentially revolutionize the global understanding of human diseases by characterizing both distinct disease states and disease…

Metabolomics of programmed cell death

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jennifer Kyle
Lipidomics is the study of cellular lipids to understand the function and structure of biological systems. The interaction of lipids with other cellular components, including proteins and…

Agile BioFoundry

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Scott Baker
This proposed EMSL Resource Owner project, is a sub-project supporting two DOE-EERE-BETO supported PNNL projects: FY16-17 four-national laboratory “Agile BioFoundry” (ABF) seed project and a larger…

Single Cell Resolution Omics Analysis of T1D islets

Lead Institution
National Institutes of Health
Principal Investigator
Charles Ansong
Type 1 diabetes mellitus (T1D) is a chronic disease resulting from the autoimmune destruction of insulin-producing pancreatic beta cells. In addition to evolving ideas about the role of beta cells in…

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…

Dissection and Deciphering of the Soil Microbiome

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Janet Jansson
This proposal aims to address key gaps in our knowledge about the composition and functional roles of the tens of thousands of microbial species in soil. Although these microorganisms carry out…

Single Cell Resolution Omics Analysis of T1D islets

Lead Institution
National Institutes of Health
Principal Investigator
Charles Ansong
Type 1 diabetes mellitus (T1D) is a chronic disease resulting from the autoimmune destruction of insulin-producing pancreatic beta cells. In addition to evolving ideas about the role of beta cells in…

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…

Single Cell Resolution Omics Analysis of T1D islets

Lead Institution
National Institutes of Health
Principal Investigator
Charles Ansong
Type 1 diabetes mellitus (T1D) is a chronic disease resulting from the autoimmune destruction of insulin-producing pancreatic beta cells. In addition to evolving ideas about the role of beta cells in…

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…

Agile BioFoundry

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jon Magnuson
This proposed EMSL Resource Owner project, is a sub-project supporting DOE-EERE-BETO supported PNNL-national laboratory Agile BioFoundry (ABF) project. PNNL’s effort for this project, which includes…

Agile BioFoundry

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Jon Magnuson
This proposed EMSL Resource Owner project, is a sub-project supporting two DOE-EERE-BETO supported PNNL projects: FY16-17 four-national laboratory “Agile BioFoundry” (ABF) seed project and a larger…