Nanospray Desorption Electrospray Ionization Mass Spectrometry
The Nanospray Desorption Electrospray Ionization Mass Spectrometer (nanoDESI) is used for a variety of environmental research projects that are relevant to atmospheric aerosol chemistry, aquatic and soil chemistry, and mass spectrometry imaging of biological samples. This resource is available to researchers worldwide through the EMSL User Program.
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Lipidomics
The Environmental Molecular Sciences Laboratory (EMSL) offers liquid chromatography tandem mass spectrometry (LC-MS) for lipidomics research, which is available through the EMSL User Program.
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Mass Spectrometry Imaging
The Environmental Molecular Sciences Laboratory's mass spectrometry capabilities allow researchers to investigate the spatial distribution of molecules within biological samples. Mass spectrometry imaging resources are available to researchers who submit proposals and are awarded funding through the EMSL User Program.
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Pyrolysis Gas Chromatography-Mass Spectrometry
The Environmental Molecular Sciences Laboratory offers pyrolysis–gas chromatography–mass spectrometry for method of chemical analysis of environmental applications, including the identification and characterization of micro- and nano-plastic contamination.
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Real Time Mass Spectrometry
The Environmental Molecular Sciences Laboratory (EMSL)'s real time mass spectrometry resources are available to researchers around the world through the EMSL User Program for understanding gas exchanges in diverse biological and environmental systems
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Cell-Free Expression Pipeline
The Environmental Molecular Sciences Laboratory's cell-free expression pipeline provides fast access to proteins or heteromeric complexes of interest.
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Cryogenic Focused Ion Beam-Scanning Electron Microscopy
The cryogenic focused ion beam-scanning electron microscope (cryo-FIB-SEM) is a semi-automated instrument that provides pseudo-three-dimensional imaging of thick samples with ~10-nm resolution or…
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Fluorescence-Activated Cell Sorting
The Environmental Molecular Sciences Laboratory (EMSL)'s Fluorescence-Activated Cell Sorter (FACS) allows collection and enrichment of unique populations of cells, or single cells, from a heterogenous culture.
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Laser Capture Dissection Microscope
The Environmental Molecular Sciences Laboratory's laser capture dissection microscope is available to the scientific community through open calls for proposals. The microscope allows researcher to collect samples of unique populations of cells based on specific morphology or fluorescent labeling.
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Liquid State NMR for Metabolomics
The Environmental Molecular Sciences Laboratory (EMSL) offers liquid state nuclear magnetic resonance capabilities for metabolomics research through the EMSL User Program.
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Liquid State NMR for Organic Matter/Complex Mixtures
The Environmental Molecular Sciences Laboratory's liquid state nuclear magnetic resonance capabilities for studying mixtures or pure compounds.
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Nanodroplet Processing in One Pot for Trace Samples (NanoPOTS)
The Environmental Molecular Sciences Laboratory offers a microfluidic sample preparation platform called Nanodroplet Processing in One Pot for Trace Samples, or nanoPOTS, for proteomics profiling of biological samples.
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Bottom-Up (Fragmented) Proteomics
The Environmental Molecular Sciences Laboratory has a variety of proteomics resources available to the scientific community through open calls for proposals.
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Top-down (Intact) Proteomics
The Environmental Molecular Sciences Laboratory's top-down proteomics resources enable researchers to measure stoichiometry of protein-protein, protein-nucleic acid, protein-ligand, and protein-metal complexes. Resources are also available for precisely defining “proteoforms” at the intact protein level. These capabilities are accessible through open calls for proposals.
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Mass Spectrometry for Organic Matter Analysis
The Environmental Molecular Sciences Laboratory offers Fourier transform ion cyclotron resonance (FTICR) mass spectrometry resources for analyzing organic matter. This instrumentation is available to researchers through open calls for proposals.
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Mass Spectrometry for Metabolomics
The Environmental Molecular Sciences Laboratory has state-of-the-art and advanced mass spectrometry platforms to perform a full range of metabolomics studies. These resources are available for use at no cost to researchers around the world through EMSL's open calls for proposals.
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Super Resolution Fluorescence Microscope
The Environmental Molecular Sciences Laboratory offers super resolution fluorescence microscopy instrumentation for analyzing cell-cell and cell-environment interactions and in-situ cellular processes.
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Soil Incubation
The Soil Incubation Laboratory at the Environmental Molecular Sciences Laboratory offers environmental chambers and incubators for conducting controlled lab studies on soils, sediment, and other environmental samples.
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cellenONE
cellenONE is a single-cell isolation and dispensing platform that is used for transcriptomics and proteomics research. Scientists can access and apply cellenONE to their research by submitting a proposal to an open call at the Environmental Molecular Sciences Laboratory (EMSL).
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Activity-Based Probes
Activity-based probes are available to researchers through the Environmental Molecular Sciences Laboratory (EMSL) User Program to help gain spatio-temporal understanding of functional proteins in biochemical processes.
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