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Richard Smith

Institution
Pacific Northwest National Laboratory
ORCID
ORCID logo 0000-0002-2381-2349

Projects

Role of Human Cytomegalovirus in the Acceleration of Vascular Disease

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
While the identification and functional characterization of HLA alleles have had widespread success in reducing the incidence of organ rejection immediately following transplantation, infection with…

Pacific Northwest Advanced Compound Identification Core

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
The capability to chemically identify thousands of metabolites and other chemicals in clinical samples will revolutionize the search for environmental, dietary, and metabolic determinants of disease…

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…

Pacific Northwest Advanced Compound Identification Core

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
The capability to chemically identify thousands of metabolites and other chemicals in clinical samples will revolutionize the search for environmental, dietary, and metabolic determinants of disease…

Alpha Project Phosphoproteomics

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Camp
The project goal is to use mass spectrometry to identify pathway proteins and the sites of their associated post-translational modifications including phosphorylation and ubiquitinylation in response…

A Systems Biology Approach to Emerging Respiratory Viral Diseases

Lead Institution
University of Washington
Principal Investigator
Michael Katze
This Systems Biology Program will comprehensively analyze and model the molecular and cellular events and pathogen-host interactions that occur during the course of respiratory virus infection. Our…

CPTAC Proteome Characterization Center

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Tao Liu
The overall objective of the PNNL Proteome Characterization Center (PCC) is to integrate genomic information with proteomic technologies to comprehensively characterize the proteome and post…

Measurements of Hydrogen Absorption in Oxidized Ti using Nuclear Reactions

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
Project type
Exploratory Research
We propose to characterize the absorption of hydrogen in Ti metal as part of our program to study hydrogen absorption in advanced aerospace materials. This study is also intended as a preliminary…

Discovery novel therapeutic protein targets by advanced MS proteomics

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Weijun Qian
The objective of this research is to discover novel therapeutic protein targets for human metabolic diseases by applying advanced PNNL proteomics technologies to a variety of tissue, cell, or…

HIV Proteomic Center for Host-Viral Response Characterization

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jon Jacobs
A Pilot Proteomics Center has been established at PNNL that will apply powerful new proteomics technologies to broadly investigate changes in protein abundances resulting from the pathologic events…

Massively Parallel Molecular Profiling of Breast Cancer

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
Molecular profiling of breast cancer into subcategories based on functional ER expression and amplification of HER2 has significantly enhanced our understanding of the disease, and has pointed the…

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…

Pacific Northwest Advanced Compound Identification Core

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
The capability to chemically identify thousands of metabolites and other chemicals in clinical samples will revolutionize the search for environmental, dietary, and metabolic determinants of disease…

Undiagnosed Diseases Network Metabolomics Core

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
A state of the art metabolomics core will be a vital part of the Undiagnosed Diseases Network (UDN). However, in order for the UDN to realize it’s the full potential it is essential that the…

Connecting genomic capabilities to physiology, photosynthesis and carbon cycling

Lead Institution
Monterey Bay Aquarium Research Institute
Principal Investigator
Alexandra Worden
Project type
Large-Scale EMSL Research
More than 50% of global primary production is performed by land plants and green algae. Of all algae green algae are the most closely related to land plants and therefore provide powerful single cell…

Pacific Northwest Advanced Compound Identification Core

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
The capability to chemically identify thousands of metabolites and other chemicals in clinical samples will revolutionize the search for environmental, dietary, and metabolic determinants of disease…

Ion Funnel Development (PNNL Scope #48165, K.Tang JPL-Ion Funnel Project)

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Keqi Tang
Project type
Exploratory Research
Design and construct an electrodynamic ion funnel and associated components suitable for interfacing with the JPL mass spectrometer and laser ablation systems. Characterize and optimize the ion…

Identification and quantification of biomarkers of malaria infection.

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Kim Hixson
This application is for the continuation of the currently closed proposal 8211 "Membrane proteins of placental parasites". We have a joint grant proposal between Richard D. Smith and Michal…

Next Generation Clinical Proteomics to Target Human Health Challenges

Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Jon Jacobs
Changes in protein expression revealed by proteomics technologies will potentially revolutionize the global understanding of human diseases by characterizing both distinct disease states and disease…

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…

Technology development in support of NCRR

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Nancy Colton
The Pacific Northwest National Laboratory (PNNL) has built a facility that already stands at the forefront of proteomic research. Moreover, the Center is uniquely poised for future developments. We…

Collaborative Research Projects Supported by the NCRR P41 Resource Center

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
David Camp
Project type
Large-Scale EMSL Research
The Proteomics Resource Center for Integrative Biology at PNNL was established in 2003 and builds on the unique instrumentation and the infrastructure provided by PNNLs EMSL facility. The mission of…

A Systems Biology Approach to Emerging Respiratory Viral Diseases

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Thomas Metz
This Systems Biology Program will comprehensively analyze and model the molecular and cellular events and pathogen-host interactions that occur during the course of respiratory virus infection. Our…

CPTAC Proteome Characterization Center

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Tao Liu
The overall objective of the PNNL Proteome Characterization Center (PCC) is to integrate genomic information with proteomic technologies to comprehensively characterize the proteome and post…

Theoretical Evaluation of Ion Funnel Focussing for Light Ions in a Drift Tube

Lead Institution
Washington State University
Principal Investigator
Bertram Jobson
Project type
Capability Research
The object of the project is to perform some ion trajectory simulations to evaluate the potential benefit of using an ion funnel to focus light ions in the Proton Transfer Reaction Mass Spectrometer …

Modeling Host Responses to Understand Severe Human Virus Infections

Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Richard Smith
This comprehensive and highly integrated systems biology program seeks to delineate the complex host responses that determine the outcome of infections with potentially lethal viruses. To achieve…