Projects

As a scientific user facility, the Environmental Molecular Sciences Laboratory (EMSL) provides expertise, instrumentation, and resources to 250 projects each year.

EMSL projects displayed on the EMSL web site project page reflect project abstracts and information migrated to this page before April 30, 2024. To review current and past EMSL user projects, visit EMSL Science Central.™

Collaborative research projects in the PNNL NIH NCRR P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

David Camp

Collaborative research projects in the PNNL NIH NCRR P41 Biomedical Technology Research Center 'Proteomics research resource for integrative biology'

NAABB Algal Biology Proteomics

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Ellen Panisko

The National Alliance for Advanced Biofuels and Bioproducts is a DOE sponsored algal fuels consortium lead by the Donald Danforth Plant Science Center. The goal of the consortium is to facilitate the…

Spatially Resolved Proteomic studies of Brains Obtained from Control Mice and Treated Mice Simulating Parkinson's Disease

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

Research on the three-dimensional transcriptome of voxelated mice brains has demonstrated that significant RNA expression differences are detectable when comparing the brain transcriptomes of…

Spatially Resolved Proteomic studies of Brains Obtained from Control Mice and Treated Mice Simulating Parkinson's Disease

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

Research on the three-dimensional transcriptome of voxelated mice brains has demonstrated that significant RNA expression differences are detectable when comparing the brain transcriptomes of…

Pacific Northwest Regional Center of Excellence (PNWRCE)Proteomics, Metabolomics, and Lipidomics Core

Lead Institution

Oregon Health & Science University

Principal Investigator

Jay Nelson

This Pacific Northwest Regional Center of Excellence (PNWRCE) exists in NIAID Region X. The two inter-related but distinct PNWRCE themes that have been selected reflect not only the scientific…

Development of a Universal Multiplex Assay System fot High-Throughput Biological Applications

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

Recent advances in genomics, proteomics, and metabolomics make the 'omics' technologies powerful discovery-based tools for identifying candidate biomarkers for human diseases; however, it…

Development and Characterization of Methods for Detection of Peptide and Carbohydrate and other Organic Markers for Bioforensics

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Christina Sorensen

In the course of a bioforensic investigation it may be desirable to characterize many aspects of the agent used, including strain identity, genetic fingerprint, method of production, and post…

Non-Linear Near-Infrared Spectroscopy Concepts for Remote Sensing

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Blake

Linear forms of LIDAR, such as fluorescence or FM-DIAL, have proved ineffective for remotely detecting low concentration or otherwise transient compounds in the atmosphere, especially under standard…

Properties of Ice and Liquid Interfaces, and Work Functions (Kay's BES-Surface Kinetics, PNNL Scope #16248)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

James Cowin

Interfaces, solid or liquid, have a unique chemistry, unlike that of any bulk phase. Ice interfaces also tend to have adherent liquid brine films in nature. This program explores interfacial effects…

Personal Black Carbon Sampler

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

James Cowin

The gold standard for exposure assessment of airborne particulate matter (PM) is personal sampling, which has traditionally been conducted by having subjects carry battery-operated pumps that…

Early Breast Cancer Biomarkers Verification (PNNL Scope #47174, RD Smith's EIF project)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Tao Liu

Our overall objective for studies performed in Years 4 to 6 is to contribute to the assembly of a highly confident protein panel for the early detection of breast cancer by applying the PNNL…

Laser Desorption from Metal Oxides and Two-photon Photoemission Electron Microscopy

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Wayne Hess

Laser interactions with nominally transparent (wide bandgap) materials are playing increasingly important roles in several technologies and applications, including chemical analysis, semiconductor…

High-Throughput Proteomics: Applications and Development (PNNL Scope #40601 and #43488)

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Gordon Anderson

This project involves the application and development of high-throughput proteomics and quantitative measurement capabilities within biological systems. More so, application measurements will be…

Proteomic Studies of type 2 diabetes using knockout models

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Weijun Qian

A central goal of diabetes research (type 1 and type 2) is to generate large numbers of functional islets or beta-cells for replacement therapy. Therefore, a fundamental knowledge of mechanisms and…

Flow Battery Research

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Cheng Huang

The main objective of this proposal is to explore electrochemical performance and solution chemistry of vanadium type flow battery and then to demonstrate a few kW prototype system. Flow battery has…

Infrared Reflectance of Solids

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Thomas Blake

Imaging technologies have been under development for more than 30 years but have only recently been proposed for comprehensive applications. The earliest public sensor and exploitation development…

Identification and quantification of biomarkers of malaria infection.

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kim Hixson

This application is for the continuation of the currently closed proposal 8211 "Membrane proteins of placental parasites". We have a joint grant proposal between Richard D. Smith and Michal…

Experimental support for Green Grid Proxies

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Kevin Regimbal

Scope: The goal of this project is to run experiments with the Green Grid industrial consortium within the Energy Smart Data Center (EMSL 1125) facility and provide experimental data to the Green…

Gas Phase Study of Solution Phase Species and Chemistry Using Variable Temperature Photoelectron Spectrometer

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Xuebin Wang

We propose to investigate solution phase species and chemistry in the gas phase using a recently developed low-temperature photoelectron spectrometer. The subjects include but not limited to,…

Non-thermal Reactions at Surfaces and Interfaces, and in Model Aqueous Systems

Lead Institution

Pacific Northwest National Laboratory

Principal Investigator

Gregory Kimmel

Energetic processes at surfaces and interfaces are important in fields such as radiation chemistry, radiation biology, waste processing, and advanced materials synthesis. Low-energy electrons (&lt…

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