Irina El Khoury
Institution
Environmental Molecular Sciences Laboratory
ORCID
Projects
Accelerating the identification of novel secondary metabolites in bioenergy plant root exudates using microcrystal electron diffraction (MicroED)
Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Vivian Lin
Project type
Cryo-EM Only
Cell-free synthesis of Influenza Virus-like particles (VLPs) as prototyping platform for vaccine development and variant characterization
Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Irina El Khoury
The molecular basis for the role of apolipoprotein A-II in cholesterol and triglyceride metabolism
Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
John Melchior
Project type
Cryo-EM Only
Accelerating the identification of novel secondary metabolites in bioenergy plant root exudates using microcrystal electron diffraction (MicroED)
Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
Vivian Lin
Unraveling New Pathways for Carbon Capture to Enhance Lipid-Biomass Feedstocks
Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
James Evans
Determining structural mechanisms of transporters and signaling networks in cellular stress responses
Lead Institution
University of Arizona
Principal Investigator
Thomas Tomasiak
Structure determination of transthyretin amyloid fibrils extracted from amyloidosis patients
Lead Institution
University of Texas Southwestern Medical Center
Principal Investigator
Lorena Saelices
Novel serine peptidases regulate the NLRP1 and CARD8 inflammasomes
Lead Institution
Boston Children's Hospital
Principal Investigator
Hao Wu
Opportunities linking omics and structural biology at PNNL: Excelling at Cryo-EM
Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
James Evans
Synthesis and Structural Probing of Protein Networks in Vitamin B6 Biosynthesis.
Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Irina El Khoury
Manganese biomineralization by the bacterial protein complex Mnx
Lead Institution
University of Washington
Principal Investigator
Bradley Tebo
Project type
Large-Scale EMSL Research
Structural studies of large clostridium toxins
Lead Institution
University of California, Irvine
Principal Investigator
Rongsheng Jin
Novel biochemical methods for facilitating GPCR tertiary and quaternary structure determination by cryo-EM.
Lead Institution
Oregon Health & Science University
Principal Investigator
David Farrens
Mechanisms of DNA damage access within the nucleosome during Base Excision Repair
Lead Institution
University of Kansas Medical Center
Principal Investigator
Bret Freudenthal
Collaborative Access Team: Pacific Northwest Cryo-EM Center (PNCC)
Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
James Evans
Structure of the first purified manganese oxidase Mnx
Lead Institution
University of Washington
Principal Investigator
Bradley Tebo
Structure determination of diversity-generating retroelements ribonucleoprotein complex by Cryo-EM
Lead Institution
University of California, San Diego
Principal Investigator
Partho Ghosh
Structural basis for SidJ-catalyzed polyglutamylation of the SidE all-in-one ubiquitin ligases
Lead Institution
University of Texas Southwestern Medical Center
Principal Investigator
Vincent Tagliabracci
Structure / Function Analysis of Positive-Strand RNA Virus Replication Complexes
Lead Institution
University of Wisconsin, Madison
Principal Investigator
Paul Ahlquist
Cryo-EM studies of heteromeric epithelial sodium channels
Lead Institution
Oregon Health & Science University
Principal Investigator
Isabelle Baconguis
Solving the Structure of Eukaryotic Type III Glutamine Synthetase Assembles
Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
James Evans
Cryo-EM studies of DNA damage response proteins
Lead Institution
Mayo Clinic
Principal Investigator
Georges Mer
Nuclear import of histone H2A-H2B and histone chaperone Nap1 by Kap114
Lead Institution
University of Texas Southwestern Medical Center
Principal Investigator
Yuh Chook
Cryo-EM studies of drug transporters
Lead Institution
Duke University
Principal Investigator
Seok-Yong Lee
Development of an Integrated Structural Mass Spectrometry Platform for Unveiling the Structure of an Unknown Protein Complex Machinery in Lignin Synthesis
Lead Institution
Environmental Molecular Sciences Laboratory
Principal Investigator
Mowei Zhou
Structural basis for recognition of receptor CSPG4 by Clostridium difficile toxin B
Lead Institution
University of California, Irvine
Principal Investigator
Rongsheng Jin
Development of Copper Storage Protein Csp1 as an Electron-Dense “Bio Tag” for Facilitating Structural Determination of Small (< 100 kDa) Proteins by single-particle Cryo EM Methods.
Lead Institution
Oregon Health & Science University
Principal Investigator
David Farrens
COVID19: Structure of COVID19 SARS-CoV-2 Spike protein in complex with monoclonal antibodies.
Lead Institution
Fred Hutchinson Cancer Research Center
Principal Investigator
Marie Pancera
Nuclear export of phosphorylated proteins by Karyopherin MSN5
Lead Institution
University of Texas Southwestern Medical Center
Principal Investigator
Yuh Chook
Structure and Function of Adenylyl Cyclase
Lead Institution
Oregon Health & Science University
Principal Investigator
Matt Whorton
Structural Mechanisms of Renal Sensory and Transport Proteins
Lead Institution
University of Utah
Principal Investigator
Erhu Cao
Structural basis of synaptic receptor trafficking by PICK1
Lead Institution
University of Pennsylvania
Principal Investigator
Roberto Dominguez
Structure and function of the membrane-bound copper-dependent methane monooxygenase in lipid nanodiscs
Lead Institution
Northwestern University
Principal Investigator
Amy Rosenzweig
Structure and function of connexin-46/50 gap junction channels
Lead Institution
Portland State University
Principal Investigator
Steve Reichow
Structure / Function Analysis of Positive-Strand RNA Virus Replication Complexes
Lead Institution
University of Wisconsin, Madison
Principal Investigator
Paul Ahlquist
Mechanistic elucidation of inflammasome biology
Lead Institution
Boston Children's Hospital
Principal Investigator
Hao Wu
Understanding the structural basis of RFX complex in regulating MHC gene expression
Lead Institution
Oregon Health & Science University
Principal Investigator
Liman Zhang
COVID-19: Structural analysis of SARS-CoV-2 proteins to understand virus immunogenicity and develop therapeutic interventions for COVID19
Lead Institution
La Jolla Institute for Immunology
Principal Investigator
Erica Saphire
Determine the structural basis of splicing modulation by small molecules
Lead Institution
University of Colorado Anschutz Medical Campus
Principal Investigator
Rui Zhao
KATP channel structures
Lead Institution
Oregon Health & Science University
Principal Investigator
Show-Ling Shyng
Structure of the TRAMP RNA surveillance complex
Lead Institution
Utah State University
Principal Investigator
Sean Johnson
Structural Mechanism of Jordan's Syndrome
Lead Institution
University of Wisconsin, Madison
Principal Investigator
Yongna Xing
Elucidating the structure of C. elegans TMC1 and TMC2
Lead Institution
Oregon Health & Science University
Principal Investigator
Eric Gouaux
Impact of apolipoprotein E isoforms on brain lipoproteins
Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
John Melchior
Structure and function of the gap junctions
Lead Institution
Portland State University
Principal Investigator
Steve Reichow
Cryo-EM studies of TRP channels
Lead Institution
Duke University
Principal Investigator
Seok-Yong Lee
CryoEM structural determinations of Bacterial Restriction-Modification systems
Lead Institution
Fred Hutchinson Cancer Research Center
Principal Investigator
Betty Shen
Cryo-EM structural analysis of Glucose-6-phosphatase catalytic subunit, G6PC1
Lead Institution
Vanderbilt University
Principal Investigator
Hassane Mchaourab
The molecular basis for the role of apolipoprotein A-II in cholesterol and triglyceride metabolism
Lead Institution
Pacific Northwest National Laboratory
Principal Investigator
John Melchior
Structure and mechanism of neurotransmitter-gated ion channels
Lead Institution
Oregon Health & Science University
Principal Investigator
Eric Gouaux